De Braekeleer M, Smith B, Lin C C
Hum Genet. 1985;69(2):112-6. doi: 10.1007/BF00293279.
We retracted information from a computerized databank which contains the cytogenetic findings of 17,000 patients with leukemia and lymphoma. Cytogenetic data from patients with solid tumors were compiled from Dr. Mitelman's catalogue on "Chromosome aberrations in cancer". We compared the observed distribution of breaks in chromosome bands involved in structural rearrangements with the random distribution of breaks generated by Monte Carlo simulation and showed that a majority but not all of the bands known to contain a fragile site are involved in structural aberrations in cancer and that some of them are associated with specific chromosome structural changes in specific types of cancer.
我们从一个计算机化数据库中提取了信息，该数据库包含17000例白血病和淋巴瘤患者的细胞遗传学研究结果。实体瘤患者的细胞遗传学数据是根据米特尔曼博士关于“癌症中的染色体畸变”的目录汇编而成的。我们将结构重排中涉及的染色体带中观察到的断裂分布与蒙特卡罗模拟产生的随机断裂分布进行了比较，结果表明，已知包含脆性位点的大多数（但不是全部）染色体带都参与了癌症中的结构畸变，并且其中一些与特定类型癌症中的特定染色体结构变化相关。
