Myhr Katrine Aagaard, Keceli Emel, Kunkel Joakim Bo, Kristensen Charlotte Burup, Vejlstrup Niels, Køber Lars, Pecini Redi
Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns Vej 7, Copenhagen, 2100, Denmark.
Cardiology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Int J Cardiovasc Imaging. 2025 Feb;41(2):199-209. doi: 10.1007/s10554-024-03291-9. Epub 2024 Dec 26.
Changes in hydration status may affect myocardial native T1 and T2 values and influence the clinical interpretation. We aimed to assess the impact of acute preload augmentation on native T1 and T2. Cardiovascular magnetic resonance (CMR) native T1 and T2 mapping were performed twice on the same day in 20 healthy participants before and after an acute preload augmentation by a 2-liter intravenous infusion of isotonic sodium chloride (0.9%). Test-retest reproducibility was evaluated in 30 healthy participants with two consecutive CMR examinations on the same day. Sixteen participants were included in both substudies. In the 20 healthy participants undergoing acute preload augmentation (55% males, mean age (interquartile range [IQR]) 43 [29-51] years), native T1 increased with 17 ms (95% confidence interval [CI] 7 to 26; p = 0.001), T2 with 1.7 ms (95% CI 0.8 to 2.4; p < 0.001), and blood T1 with 46 ms (95% CI 28 to 65; p < 0.001). Test-retest variability in 30 healthy participants (47% males, median age 43 [28-52] years) showed 95% limits of agreement (LOA) of ± 26 ms for native T1, ± 2.1 ms for T2, and ± 57 ms for blood T1. In the 16 participants included in both substudies, the mean differences in changes post-infusion versus test-retest were 22 ms (95% CI 8 to 36; p = 0.01) for native T1, 1.9 ms (95% CI 0.9 to 2.9; p = 0.001) for T2, and 62 ms (95% CI 32 to 91; p < 0.001) for blood T1. Native T1 and T2 values increased following acute preload augmentation. However, the changes were within the 95% LOA of the test-retest reproducibility.
水化状态的改变可能会影响心肌的固有T1和T2值，并影响临床解读。我们旨在评估急性前负荷增加对固有T1和T2的影响。在20名健康参与者中，通过静脉输注2升等渗氯化钠（0.9%）进行急性前负荷增加前后，于同一天进行了两次心血管磁共振（CMR）固有T1和T2成像。在30名健康参与者中，通过同一天连续两次CMR检查评估了重测重复性。两个亚研究都纳入了16名参与者。在20名接受急性前负荷增加的健康参与者中（55%为男性，平均年龄（四分位间距[IQR]）43[29 - 51]岁），固有T1增加了17毫秒（95%置信区间[CI]7至26；p = 0.001），T2增加了1.7毫秒（95%CI 0.8至2.4；p < 0.001），血液T1增加了46毫秒（95%CI 28至65；p < 0.001）。30名健康参与者（47%为男性，中位年龄43[28 - 52]岁）的重测变异性显示，固有T1的95%一致性界限（LOA）为±26毫秒，T2为±2.1毫秒，血液T1为±57毫秒。在两个亚研究都纳入的16名参与者中，输注后变化与重测的平均差异，固有T1为22毫秒（95%CI 8至36；p = 0.01），T2为1.9毫秒（95%CI 0.9至2.9；p = 0.001），血液T1为62毫秒（95%CI 32至91；p < 0.001）。急性前负荷增加后，固有T1和T2值升高。然而，这些变化在重测重复性的95%LOA范围内。
