Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Department of Pediatric Hematology/Oncology, Juliane Marie Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Eur Heart J Cardiovasc Imaging. 2024 Jul 31;25(8):1109-1117. doi: 10.1093/ehjci/jeae070.
Cardiovascular diseases manifest differently in males and females, potentially influenced by inherent sex- and age-related differences in myocardial tissue composition. Such inherent differences are not well-established in the literature. With this study using cardiac magnetic resonance (CMR) native T1 mapping, we aim to determine the effect of sex and age on myocardial tissue composition in healthy individuals.
CMR native T1 mapping was performed in 276 healthy individuals (55% male, age 8---84 years) on a 1.5 Tesla scanner using a MOLLI 5(3)3 acquisition scheme. Additionally, 30 healthy participants (47% male, age 24-68 years) underwent a 1-year follow-up CMR to assess the longitudinal changes of native T1. Mean native T1 values were 1000 ± 22 ms in males and 1022 ± 23 ms in females [mean difference (MD) = 22 ms, 95% confidence interval (CI) (17, 27)]. Female sex was associated with higher native T1 in multivariable linear regression adjusting for age, heart rate, left ventricular mass index, and blood T1 [β=10 ms, 95% CI (3.4, 15.8)]. There was no significant interaction between sex and age (P = 0.27). Further, age was not associated with native T1 [β=0.1 ms, 95% CI (-0.02, 0.2)], and native T1 did not change during a 1-year period [MD -4 ms, 95% CI (-11, 3)].
Female sex was associated with higher native T1; however, there was no association between age and native T1. Additionally, there was no evidence of an interaction between sex and age. Our findings indicate intrinsic sex-based disparities in myocardial tissue composition.
心血管疾病在男性和女性中的表现不同，这可能受到心肌组织成分中固有的性别和年龄相关差异的影响。这种内在差异在文献中尚未得到很好的确立。本研究使用心脏磁共振（CMR）原生 T1 映射，旨在确定性别和年龄对健康个体心肌组织成分的影响。
在 1.5T 扫描仪上使用 MOLLI 5(3)3 采集方案对 276 名健康个体（55%为男性，年龄 8-84 岁）进行 CMR 原生 T1 映射。此外，30 名健康参与者（47%为男性，年龄 24-68 岁）接受了为期 1 年的 CMR 随访，以评估原生 T1 的纵向变化。男性的平均原生 T1 值为 1000±22ms，女性为 1022±23ms[平均差值（MD）=22ms，95%置信区间（CI）（17，27）]。在多变量线性回归中，调整年龄、心率、左心室质量指数和血液 T1 后，女性性别与较高的原生 T1 相关[β=10ms，95%CI（3.4，15.8）]。性别和年龄之间没有显著的交互作用（P=0.27）。此外，年龄与原生 T1 无关[β=0.1ms，95%CI（-0.02，0.2）]，并且在 1 年内原生 T1 没有变化[MD=-4ms，95%CI（-11，3）]。
女性性别与较高的原生 T1 相关；然而，年龄与原生 T1 之间没有关联。此外，性别和年龄之间没有交互作用的证据。我们的研究结果表明心肌组织成分中存在固有的性别差异。
