Fillion Alexandre, Boutin Amélie, Giguère Yves, Forest Jean-Claude, Ghesquière Louise, Bujold Emmanuel
Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec, QC; Centre de recherche du CHU de Québec - Université Laval, Québec, QC.
Centre de recherche du CHU de Québec - Université Laval, Québec, QC; Department of Pediatrics, Faculty of Medicine, Université Laval, Québec, QC.
J Obstet Gynaecol Can. 2025 Feb;47(2):102753. doi: 10.1016/j.jogc.2024.102753. Epub 2024 Dec 24.
While soluble fms-like tyrosine kinase 1 (sFlt-1) is used to predict preeclampsia (PE) and its severity in late pregnancy, we aimed to clarify its role in early pregnancy. Using prospective cohorts, we estimated the association between sFlt-1, adjusted for gestational age, and preterm PE. sFlt-1 was significantly decreased in the first trimester, mostly before the 13th week, and significantly increased in the third trimester in those who developed preterm PE and particularly early-onset PE. We hypothesize that sFlt-1 evolves from low to high values in early to late pregnancy among women with preterm and early-onset PE.
虽然可溶性fms样酪氨酸激酶1（sFlt-1）用于预测晚期妊娠子痫前期（PE）及其严重程度，但我们旨在阐明其在早期妊娠中的作用。我们采用前瞻性队列研究，评估校正孕周后的sFlt-1与早产型PE之间的关联。sFlt-1在孕早期显著降低，大多在孕13周前，而在发生早产型PE尤其是早发型PE的孕妇中，sFlt-1在孕晚期显著升高。我们推测，早产型和早发型PE女性的sFlt-1在妊娠早期至晚期从低值向高值演变。
