Businge Charles Bitamazire, Longo-Mbenza Benjamin, Kengne Andre Pascal
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5117, South Africa.
Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Medicina (Kaunas). 2025 Mar 26;61(4):600. doi: 10.3390/medicina61040600.
: Several micro- and macro-nutrient malnutrition states that are routinely assessed during clinical care of women in the antenatal period have been proposed as risk factors for preeclampsia. However, there is a paucity of data on the potential use of these biomarkers for detection of preeclampsia. The aim of this case-control study was to investigate the association of biomarkers from routine clinical tests, and those specific to micro- and macro-nutrient malnutrition, with the risk of preeclampsia. : Venous blood samples of 250 participants with preeclampsia and 150 pregnant women without preeclampsia were collected and assayed immediately for the full blood count, urea and electrolytes, high-density cholesterol (HDL), total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), oxidized low-density lipoprotein cholesterol (OxLDL), and selenium, in addition to urine iodine concentration (UIC). : The serum potassium/magnesium ratio (K/Mg), UIC, fasting plasma glucose (FPG), thyroid stimulating hormone (TSH), lymphocyte percentage (L/WBC%), and the oxidized LDL/albumin ratio (OxLDL/Alb) were identified as independent predictors of preeclampsia. : Serum potassium/magnesium ratio and other analytes essential for various biological processes, some of which are assayed during routine care, were significantly associated with preeclampsia, warranting further exploration as potential screening biomarkers in low-resource settings.
在孕期妇女的临床护理中，几种经常评估的微量和宏量营养素营养不良状态已被提出作为子痫前期的危险因素。然而，关于这些生物标志物在子痫前期检测中的潜在用途的数据却很匮乏。本病例对照研究的目的是调查常规临床检测中的生物标志物以及微量和宏量营养素营养不良特异性生物标志物与子痫前期风险之间的关联。收集了250例子痫前期患者和150例未患子痫前期的孕妇的静脉血样本，并立即对全血细胞计数、尿素和电解质、高密度胆固醇（HDL）、总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL）、氧化型低密度脂蛋白胆固醇（OxLDL）和硒进行检测，此外还检测了尿碘浓度（UIC）。血清钾/镁比值（K/Mg）、UIC、空腹血糖（FPG）、促甲状腺激素（TSH）、淋巴细胞百分比（L/WBC%）以及氧化型LDL/白蛋白比值（OxLDL/Alb）被确定为子痫前期的独立预测指标。血清钾/镁比值以及各种生物过程所必需的其他分析物，其中一些在常规护理中进行检测，与子痫前期显著相关，值得在资源匮乏地区作为潜在的筛查生物标志物进行进一步探索。
