Injectable dual-network hyaluronic acid nanocomposite hydrogel for prevention of postoperative breast cancer recurrence and wound healing.

High locoregional recurrence rates and potential wound infections remain a significant challenge for postoperative breast cancer patients. Herein, we developed a dual-network hyaluronic acid (HA) nanocomposite hydrogel composed of herring sperm DNA (hsDNA) bridged methacrylated HA (HAMA) and FeMg-LDH-ppsa nanohybrid chelated catechol-modified HA (HADA) for the prevention of breast cancer recurrent, anti-infection, and promoting wound healing. Dynamic reversible hsDNA cross-linking combined with metal-catechol chelating renders the hydrogel injectability, rapid self-healing ability, and enhanced mechanical properties. FeMg-LDH-ppsa nanohybrids obtained by in situ polymerization of aniline derivatives in the FeMg-LDH interlayer exhibited excellent photothermal effect. Upon near-infrared (NIR) irradiation, the photothermal effect mediated by FeMg-LDH-ppsa can unwind the hsDNA duplex, enabling the controlled release of preloaded DOX for synergistic photothermal-chemotherapy antitumor. Meanwhile, the catechol-metal (Fe/Mg) moieties in the hydrogel enhanced tissue adhesion and exhibited intrinsic antimicrobial and bioactive properties, which in combination with the NIR-assisted photothermal effect, significantly accelerated infected wound healing through sterilizing microorganisms, alleviating inflammation, re-epithelialization, and angiogenesis. Overall, this multifunctional hydrogel represented a promising candidate in postoperative wound management for simultaneous tumor elimination, antiinfection, and wound repair.