[儿童血清胃饥饿素与肝脏表达抗菌肽-2水平和特发性矮小的相关性]
[Correlation between serum ghrelin and liver-expressed antimicrobial peptide-2 with idiopathic short stature in children].
作者信息
Liu Qing, Zhang Wei-Chun, Chen Bo, Song Ya-Wen
机构信息
Department of Pediatrics, First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang 832008, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2024 Dec 15;26(12):1261-1266. doi: 10.7499/j.issn.1008-8830.2404038.
OBJECTIVES
To investigate the expression levels of ghrelin and liver-expressed antimicrobial peptide-2 (LEAP-2) in children with idiopathic short stature (ISS) to provide reference for further understanding the etiology of short stature.
METHODS
A prospective study was conducted from December 2021 to October 2023, involving 46 children diagnosed with ISS (ISS group) and 46 healthy children with normal height (control group) at the First Affiliated Hospital of Shihezi University. General data and serum levels of ghrelin and LEAP-2 were compared between the two groups. The predictive value of these two indicators for ISS was evaluated using receiver operating characteristic (ROC) curve analysis.
RESULTS
The serum level of ghrelin in the ISS group was higher than that in the control group, while the level of LEAP-2 was lower (<0.05). The ratio of LEAP-2 to ghrelin was lower in the ISS group compared to the control group (<0.05). Multivariate logistic regression analysis showed that HtSDS, IGF-1, ghrelin, LEAP-2, and the ratio of LEAP-2/ghrelin were independently associated with the occurrence of ISS (<0.05). ROC curve analysis indicated that the AUCs for ghrelin, LEAP-2, the ratio of ghrelin to LEAP-2, and their combination in predicting ISS were all >0.8. The optimal cutoff values for ghrelin, LEAP-2, and the LEAP-2/ghrelin ratio were 5 607 pg/mL, 1 155 pg/mL, and 0.212, respectively. In children with ISS, ghrelin showed a negative correlation with chronological age, LEAP-2, and the LEAP-2/ghrelin ratio (<0.05), while it was positively correlated with growth rate and peak growth hormone levels (<0.05). LEAP-2 was negatively correlated with growth rate, peak growth hormone levels, and ghrelin (<0.05), but positively correlated with chronological age and the LEAP-2/ghrelin ratio (<0.05).
CONCLUSIONS
Ghrelin and LEAP-2 are correlated with the occurrence of ISS, which may provide references for the diagnosis and etiological analysis of children with ISS.
目的
探讨生长激素释放肽（ghrelin）和肝脏表达抗菌肽-2（LEAP-2）在特发性矮小（ISS）儿童中的表达水平，为进一步了解矮小症病因提供参考。
方法
2021年12月至2023年10月进行一项前瞻性研究，纳入石河子大学第一附属医院46例诊断为ISS的儿童（ISS组）和46例身高正常的健康儿童（对照组）。比较两组的一般资料以及ghrelin和LEAP-2的血清水平。采用受试者工作特征（ROC）曲线分析评估这两个指标对ISS的预测价值。
结果
ISS组血清ghrelin水平高于对照组，而LEAP-2水平低于对照组（<0.05）。ISS组LEAP-2与ghrelin的比值低于对照组（<0.05）。多因素logistic回归分析显示，身高标准差分值（HtSDS）、胰岛素样生长因子-1（IGF-1）、ghrelin、LEAP-2以及LEAP-2/ghrelin比值与ISS的发生独立相关（<0.05）。ROC曲线分析表明，ghrelin、LEAP-2、ghrelin与LEAP-2的比值及其联合预测ISS的曲线下面积（AUC）均>0.8。ghrelin、LEAP-2以及LEAP-2/ghrelin比值的最佳截断值分别为5 607 pg/mL、1 155 pg/mL和0.212。在ISS儿童中，ghrelin与实足年龄、LEAP-2以及LEAP-2/ghrelin比值呈负相关（<0.05），而与生长速率和生长激素峰值水平呈正相关（<0.05）。LEAP-2与生长速率、生长激素峰值水平和ghrelin呈负相关（<0.05），但与实足年龄和LEAP-2/ghrelin比值呈正相关（<0.05）。
结论
Ghrelin和LEAP-2与ISS的发生相关，可为ISS儿童的诊断和病因分析提供参考。
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