Tong Xin, Chen Meiyuan, Wang Xiangyu, Han Wei, Zhang Dongxing, Xiao Jing, Tian Ye
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100032, PR China.
Institute of Urology, Beijing Municipal Health Commission, Beijing, PR China.
BMC Urol. 2024 Dec 27;24(1):285. doi: 10.1186/s12894-024-01678-3.
A ureteric stone is a type of urinary tract stone that is found within the ureter. While most cases can be managed with conservative treatment or minimally invasive surgery, these methods often cause significant pain for the patient. Interestingly, a new type of ureteroscope has shown considerable promise in treating patients with ureteric stones, and this study aims to explore its clinical application.
A total of 120 patients with ureteric stones were recruited from our hospitals between January 1, 2023, and December 31, 2023. These patients were randomly assigned to either the control group, which received the traditional straight ureteroscope, or the experimental group, which was treated with the new type of ureteroscope. Both groups provided general data and blood samples for further analysis. A logistic regression analysis was conducted to examine the factors influencing infection following surgery in patients with ureteric stones, including preoperative CRP greater than 8 mg/L, postoperative CRP greater than 8 mg/L, preoperative white blood cell count (> 10/L), postoperative white blood cell count (> 10/L), preoperative urinalysis count greater than 28 (/ul), postoperative urinalysis count greater than 28 (/ul), and urine routine leukocyte count.
The findings indicated no significant differences between the observation group and the control group regarding preoperative demographic, participants general data (P > 0.05). Postoperative CRP > 8 mg/L, white blood cell count > 10 × 10/L, urinalysis count > 28/µL, and urine leukocyte count significantly decreased in the experimental group compared to the control group (P < 0.05). Binary logistic regression showed that postoperative CRP > 8 mg/L (OR = 7.03), white blood cell count > 109/L (OR = 3.86), urinalysis count > 28/µL (OR = 2.83), and urine leukocyte count (OR = 1.004) were predictive factors for ureteric stones. Preoperative values showed no significant difference (P > 0.05).
The binary logistic regression analysis identified Postoperative CRP > 8 mg/L, white blood cell count > 10 × 10/L, urinalysis count > 28/µL, and urine leukocyte count as significant predictors of postoperative infections. Our research findings indicate that the new ureteroscope has significant advantages over traditional ureteroscopes in terms of ease of entry into the ureteral lumen, stone fragmentation angle during surgery, surgical field of view, surgical operability, and reducing the risk of postoperative potential infections. These characteristics demonstrate that the new ureteroscope has significant potential in clinical applications, warranting further promotion and use.
输尿管结石是一种存在于输尿管内的泌尿系统结石。虽然大多数病例可通过保守治疗或微创手术处理，但这些方法常常给患者带来剧痛。有趣的是，一种新型输尿管镜在治疗输尿管结石患者方面显示出了巨大潜力，本研究旨在探索其临床应用。
2023年1月1日至2023年12月31日期间，从我院招募了120例输尿管结石患者。这些患者被随机分为对照组（接受传统直输尿管镜）和实验组（接受新型输尿管镜治疗）。两组均提供一般资料和血液样本以供进一步分析。进行逻辑回归分析，以检查影响输尿管结石患者术后感染的因素，包括术前CRP大于8mg/L、术后CRP大于8mg/L、术前白细胞计数（>10/L）、术后白细胞计数（>10/L）、术前尿常规计数大于28（/ul）、术后尿常规计数大于28（/ul）以及尿白细胞计数。
研究结果表明，观察组和对照组在术前人口统计学、参与者一般资料方面无显著差异（P>0.05）。与对照组相比，实验组术后CRP>8mg/L、白细胞计数>10×10/L、尿常规计数>28/µL以及尿白细胞计数显著降低（P<0.05）。二元逻辑回归显示，术后CRP>8mg/L（OR=7.03）、白细胞计数>109/L（OR=3.86）、尿常规计数>28/µL（OR=2.83）以及尿白细胞计数（OR=1.004）是输尿管结石的预测因素。术前值无显著差异（P>0.05）。
二元逻辑回归分析确定术后CRP>8mg/L、白细胞计数>10×10/L、尿常规计数>28/µL以及尿白细胞计数是术后感染的重要预测指标。我们的研究结果表明，新型输尿管镜在进入输尿管腔的难易程度、手术中结石破碎角度、手术视野、手术可操作性以及降低术后潜在感染风险方面比传统输尿管镜具有显著优势。这些特性表明新型输尿管镜在临床应用中具有巨大潜力，值得进一步推广和使用。
