Carrazana Elizabeth, Salvadores Natalia
Laboratory of Neurodegenerative Diseases, Center for Biomedicine, Universidad Mayor, Temuco, Chile.
Alzheimers Res Ther. 2024 Dec 26;16(1):275. doi: 10.1186/s13195-024-01649-8.
In recent years, a growing body of research has unveiled the involvement of the necroptosis pathway in the pathogenesis of Alzheimer's disease (AD). This evidence has shed light on the mechanisms underlying neuronal death in AD, positioning necroptosis at the forefront as a potential target for therapeutic intervention. This review provides an update on the current knowledge on this emerging, yet rapidly advancing topic, encompassing all published studies that present supporting proof of the role of the necroptosis pathway in the neurodegenerative processes of AD. The implication of misfolded tau and amyloid-β (Aβ) aggregates is highlighted, with evidence suggesting their direct or indirect involvement in necroptosis activation. In summary, the review underscores the significance of understanding the complex interplay between necroptosis, protein aggregates, and neurodegeneration in AD. The findings advocate for a comprehensive approach, combining therapeutic and early diagnostic strategies, to intervene in the disease process before irreversible damage occurs.
近年来，越来越多的研究揭示了坏死性凋亡途径在阿尔茨海默病（AD）发病机制中的作用。这些证据阐明了AD中神经元死亡的潜在机制，使坏死性凋亡成为治疗干预的一个潜在前沿靶点。本综述对这一新兴且发展迅速的主题的当前知识进行了更新，涵盖了所有发表的表明坏死性凋亡途径在AD神经退行性过程中作用的支持性证据的研究。错误折叠的tau蛋白和淀粉样β（Aβ）聚集体的影响得到了强调，有证据表明它们直接或间接参与坏死性凋亡的激活。总之，该综述强调了理解AD中坏死性凋亡、蛋白质聚集体和神经退行性变之间复杂相互作用的重要性。这些发现提倡采用综合方法，结合治疗和早期诊断策略，在不可逆损伤发生之前干预疾病进程。
