妊娠期猴痘病毒感染：向哥伦比亚国立卫生研究院报告的两例病例描述

Monkeypox virus infection in pregnancy: description of two cases reported to the Colombian National Institute of Health.

作者信息

Marcela Mercado-Reyes, Marcela Daza, Yazmín Rodríguez Peña, Paula Araque Muñoz, Carlos Franco-Muñoz, Hector Ruíz-Moreno, Sheryll Corchuelo Chavarro, Claudia Portilla Velandia, Johana Osorio Usaquén, Greace Ávila Mellizo, Nubia Narvaez Díaz, Diana Walteros, Katherinne Cortes Palacio, Ángel Piñeros Daza José

机构信息

National Institute of Health, Bogotá D.C, Colombia.

Clínica del Country, Infectious Diseases Service, Bogotá D.C, Colombia.

出版信息

APMIS. 2025 Jan;133(1):e13488. doi: 10.1111/apm.13488.

DOI:10.1111/apm.13488

PMID:39726259

Abstract

Monkeypox (mpox), caused by the MPOXV (monkeypox virus), has been endemic in Africa since its first identification in 1958. However, in May 2022, the world witnessed the first global outbreak associated with the West African clade. Even though thousands of cases have been recorded, our understanding of vertical transmission during pregnancy remains restricted due to an absence of reported cases in pregnant women and a lack of adequate clinical descriptions. The cases of two pregnant women, ages 33 and 24, who tested positive for MPOXV at 31 and 13.4 weeks of gestation, respectively, are presented. In all cases, extensive clinical, histological, and molecular examinations of the mothers and neonates revealed no indication of vertical transmission.

摘要

猴痘（mpox）由猴痘病毒（MPOXV）引起，自1958年首次发现以来在非洲一直呈地方性流行。然而，2022年5月，全球见证了首例与西非分支相关的全球疫情。尽管已记录了数千例病例，但由于孕妇中缺乏报告病例以及缺乏充分的临床描述，我们对孕期垂直传播的了解仍然有限。本文介绍了两名分别为33岁和24岁的孕妇病例，她们在妊娠31周和13.4周时猴痘病毒检测呈阳性。在所有病例中，对母亲和新生儿进行的广泛临床、组织学和分子检查均未发现垂直传播的迹象。