Obara H, Pappas C T, Northway W H, Bensch K G
Int J Radiat Oncol Biol Phys. 1985 Feb;11(2):285-98. doi: 10.1016/0360-3016(85)90151-8.
Prolonged inhalation of 80% oxygen, in contrast to 100% oxygen, has generally been assumed not to lead to significant pulmonary impairment. Two and six week old C57BL mice were systematically assessed by transmission and scanning electron microscopy for structural changes in the lung caused by inhalation of 80% and 100% oxygen from the first day of life, and the injury was quantitated morphometrically. Six weeks of continuous inhalation of 80% oxygen resulted in diffuse fibrosis of the gas exchanging parts of the lung superimposed on which were, in the 100% oxygen exposed mice, foci of coarse scarring. Lowering the inspired oxygen concentration from 100% to 80% appeared to reduce the mucosal injury more than the interstitial fibrotic response. This suggests that the most persistent alteration caused by chronic supplemental oxygen exposure below 80% will be interstitial fibrosis.
与吸入100%氧气相比，长期吸入80%氧气通常被认为不会导致严重的肺部损伤。从出生第一天起，对2周龄和6周龄的C57BL小鼠通过透射电子显微镜和扫描电子显微镜系统评估吸入80%和100%氧气对肺部结构的影响，并对损伤进行形态计量学定量分析。连续六周吸入80%氧气导致肺气体交换部分出现弥漫性纤维化，而在吸入100%氧气的小鼠中，在此基础上叠加有粗大瘢痕灶。将吸入氧气浓度从100%降至80%似乎比间质纤维化反应更能减轻黏膜损伤。这表明，低于80%的慢性补充氧气暴露所导致的最持久变化将是间质纤维化。
