Hackett Katherine, Shi Yidan, Schankel Laura, Oliveira Nicole, Kelley Melissa, McCoubrey Hannah, Peskin Sara Manning, O'Brien Kyra, Xie Sharon X, Wolk David, Mechanic-Hamilton Dawn
Department of Psychology and Neuroscience Temple University Philadelphia Pennsylvania USA.
Present address: Division of General Internal Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA.
Alzheimers Dement (Amst). 2024 Dec 26;16(4):e70043. doi: 10.1002/dad2.70043. eCollection 2024 Oct-Dec.
We investigated the feasibility and validity of the remotely-administered neuropsychological battery from the National Alzheimer's Coordinating Center Uniform Data Set (UDS T-Cog).
Two hundred twenty Penn Alzheimer's Disease Research Center participants with unimpaired cognition, mild cognitive impairment, and dementia completed the T-Cog during their annual UDS evaluation. We assessed administration feasibility and diagnostic group differences cross-sectionally across telephone versus videoconference modalities, and compared T-Cog to prior in-person UDS scores longitudinally.
Administration time averaged 54 min and 79% of participants who initiated a T-Cog completed all 12 subtests; completion time and rates differed by diagnostic group but not by modality. Performance varied expectedly across groups with moderate to strong associations between most T-Cog measures and in-person correlates, although select subtests demonstrated lower comparability.
The T-Cog is feasibly administered and shows preliminary validity in a cognitively heterogeneous cohort. Normative data from this cohort should be expanded to more diverse populations to enhance utility and generalizability.
This study examined the feasibility and validity of the remote Uniform Data Set (also known as the T-Cog) and contributes key normative data for widespread use.A remote neuropsychological battery was feasibly administered with high overall engagement and completion rates, adequate reliability compared to in-person testing, and evidence of validity across diagnostic groups.Typical barriers to administration included hearing impairment, technology issues, and distractions; hearing difficulties were particularly common among cognitively impaired groups.Certain tests were less closely related to their in-person correlates and should be used with caution.
我们研究了来自国家阿尔茨海默病协调中心统一数据集（UDS T-Cog）的远程管理神经心理测试组合的可行性和有效性。
220名宾夕法尼亚阿尔茨海默病研究中心的参与者，他们认知功能未受损、有轻度认知障碍和痴呆，在年度UDS评估期间完成了T-Cog测试。我们横断面评估了通过电话与视频会议方式进行测试的管理可行性以及诊断组差异，并纵向比较了T-Cog与之前现场UDS评分。
测试管理平均用时54分钟，启动T-Cog测试的参与者中有79%完成了所有12个分测试；完成时间和完成率因诊断组而异，但不因测试方式而异。各诊断组的表现符合预期，大多数T-Cog测试指标与现场测试指标之间存在中度到强的相关性，不过部分分测试的可比性较低。
T-Cog测试管理可行，且在认知功能异质性队列中显示出初步有效性。该队列的常模数据应扩展到更多样化的人群，以提高实用性和普遍性。
本研究检验了远程统一数据集（也称为T-Cog）的可行性和有效性，并为广泛应用贡献了关键的常模数据。远程神经心理测试组合管理可行，总体参与度和完成率高，与现场测试相比具有足够的可靠性，且在各诊断组中均有有效性证据。测试管理的典型障碍包括听力障碍、技术问题和干扰因素；听力困难在认知受损组中尤为常见。某些测试与现场测试指标的相关性较低，应谨慎使用。
