Mickle Angela M, Tanner Jared J, Holmes Udell, Rashid Ahmed, Barolette Olivier, Addison Brittany, Sambuco Nicola, Garvan Cynthia, Lai Song, Seubert Christoph, Schmidt Siegfried, Staud Roland, Edberg Jeffrey C, Redden David, Goodin Burel R, Price Catherine C, Fillingim Roger B, Sibille Kimberly T
Department of Physical Medicine & Rehabilitation, College of Medicine, University of Florida, Gainesville, FL, USA.
Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
Pain Rep. 2024 Dec 24;10(1):e1225. doi: 10.1097/PR9.0000000000001225. eCollection 2025 Feb.
Factors contributing to individual differences in knee osteoarthritis remain elusive. Dispositional traits and socioeconomic status are independent predictors of mental and physical health, although significant variability remains. Dispositional traits serve as the biological interface for life experiences.
We investigate group differences based on dispositional traits and poverty status, specific to (1) pain intensity and functional limitations and (2) biological measures, a clinical composite and brain age.
Adults aged 45 to 85 years with knee pain associated with chronic musculoskeletal pain provided information on demographics, socioeconomic and psychosocial factors, pain, and physical function. Kellgren-Lawrence scores were determined from knee radiographs, the clinical composite from fasting blood draws, and brain age from MRI data.
One hundred seventy-three individuals participated in the study. Of those, 117 had protective dispositional traits (81 above poverty/36 in poverty), and 56 had vulnerable dispositional traits (24 above poverty/32 in poverty). With sex, study site, Kellgren-Lawrence score, and age/or image quality as covariates, significant group differences were observed across clinical pain ( < 0.001), functional limitations ( ≤ 0.001), and brain age ( ≤ 0.002) measures. Although not significant, the clinical composite measure aligned with the other outcome measures and demonstrated the hormesis inverted U pattern.
Groups based on dispositional traits and socioeconomic status explain differing clinical outcomes. Consistent with the allostatic load and hormesis inverted U models, one group was in an adaptive health status, 2 groups were showing signs of developing load, and the fourth group showing signs of overload, at risk of worse health outcomes.
导致膝关节骨关节炎个体差异的因素仍不明确。尽管仍存在显著变异性，但性格特质和社会经济地位是心理和身体健康的独立预测因素。性格特质是生活经历的生物学界面。
我们基于性格特质和贫困状况调查组间差异，具体涉及（1）疼痛强度和功能受限情况，以及（2）生物学指标、临床综合指标和脑龄。
年龄在45至85岁之间、患有与慢性肌肉骨骼疼痛相关的膝关节疼痛的成年人提供了有关人口统计学、社会经济和心理社会因素、疼痛及身体功能的信息。通过膝关节X光片确定凯尔格伦-劳伦斯评分，通过空腹抽血确定临床综合指标，通过MRI数据确定脑龄。
173人参与了该研究。其中，117人具有保护性性格特质（81人处于贫困线以上/36人处于贫困线以下），56人具有易损性格特质（24人处于贫困线以上/32人处于贫困线以下）。以性别、研究地点、凯尔格伦-劳伦斯评分以及年龄/图像质量作为协变量，在临床疼痛（<0.001）、功能受限（≤0.001）和脑龄（≤0.002）指标方面观察到显著的组间差异。尽管不显著，但临床综合指标与其他结果指标一致，并呈现出应激适应的倒U型模式。
基于性格特质和社会经济地位的分组解释了不同的临床结果。与应激负荷和应激适应倒U型模型一致，一组处于适应性健康状态，两组显示出发展为负荷的迹象，第四组显示出超负荷的迹象，面临更差健康结果的风险。
