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Could encapsulation of natural compounds in BBB-permeable nanocarriers produce effective Alzheimer's disease treatments?

作者信息

Ramalho Maria João, Andrade Stéphanie, Loureiro Joana Angélica, Pereira Maria Carmo

机构信息

LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Porto, Portugal.

ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.

出版信息

Nanomedicine (Lond). 2025 Mar;20(5):435-438. doi: 10.1080/17435889.2024.2444859. Epub 2024 Dec 27.

DOI:10.1080/17435889.2024.2444859
PMID:39727082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11875461/
Abstract
摘要

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本文引用的文献

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Blood-Brain Barrier-Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience.血脑屏障靶向纳米颗粒：生物材料特性及其在转化神经科学中的生物医学应用
Pharmaceuticals (Basel). 2024 May 10;17(5):612. doi: 10.3390/ph17050612.
2
An Ultrasmall Cu/CuO Nanoparticle-Based Diselenide-Bridged Nanoplatform Mediating Reactive Oxygen Species Scavenging and Neuronal Membrane Enhancement for Targeted Therapy of Ischemic Stroke.一种基于超小 Cu/CuO 纳米粒子的二硒键桥连纳米平台，用于介导活性氧物种清除和神经元膜增强，实现缺血性脑卒中的靶向治疗。
ACS Nano. 2024 Feb 6;18(5):4140-4158. doi: 10.1021/acsnano.3c08734. Epub 2023 Dec 22.
3
Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against Neurodegenerative Disorders.脂质纳米颗粒、细胞穿透肽和生物活性肽在开发针对神经退行性疾病的脑靶向纳米药物中的最新应用
Nanomaterials (Basel). 2023 Nov 23;13(23):3004. doi: 10.3390/nano13233004.
4
Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease.抗淀粉样蛋白单克隆抗体治疗阿尔茨海默病。
BioDrugs. 2024 Jan;38(1):5-22. doi: 10.1007/s40259-023-00633-2. Epub 2023 Nov 13.
5
Challenges in Permeability Assessment for Oral Drug Product Development.口服药物产品开发中渗透性评估的挑战。
Pharmaceutics. 2023 Sep 28;15(10):2397. doi: 10.3390/pharmaceutics15102397.
6
A New Perspective for the Treatment of Alzheimer's Disease: Exosome-like Liposomes to Deliver Natural Compounds and RNA Therapies.阿尔茨海默病治疗的新视角：外泌体样脂质体递送天然化合物和 RNA 疗法。
Molecules. 2023 Aug 11;28(16):6015. doi: 10.3390/molecules28166015.
7
Transcranial application of magnetic pulses for improving brain drug delivery efficiency via intranasal injection of magnetic nanoparticles.通过经鼻注射磁性纳米颗粒，经颅施加磁脉冲以提高脑内药物递送效率。
Biomed Eng Lett. 2023 Mar 13;13(3):417-427. doi: 10.1007/s13534-023-00272-0. eCollection 2023 Aug.
8
Protein corona: Friend or foe? Co-opting serum proteins for nanoparticle delivery.蛋白质冠：是敌是友？利用血清蛋白进行纳米颗粒递药。
Adv Drug Deliv Rev. 2023 Jan;192:114635. doi: 10.1016/j.addr.2022.114635. Epub 2022 Nov 26.
9
Exosome-based approaches in the management of Alzheimer's disease.基于外泌体的阿尔茨海默病治疗方法。
Neurosci Biobehav Rev. 2023 Jan;144:104974. doi: 10.1016/j.neubiorev.2022.104974. Epub 2022 Nov 23.
10
Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2019.1990 - 2019年全球、区域及国家层面阿尔茨海默病和其他痴呆症的负担
Front Aging Neurosci. 2022 Oct 10;14:937486. doi: 10.3389/fnagi.2022.937486. eCollection 2022.