Drabkin Sacha, Maniaci Antonino, Lentini Mario, Iannella Giannicola, Tainmont Sophie, Lelubre Christophe, Mat Quentin
Department of Otorhinolaryngology, Centre Hospitalier Universitaire de Charleroi, Chaussée de Bruxelles 140, 6042 Charleroi, Belgium.
Otology Study Group, Young Otolaryngologists-International Federation of Otorhinolaryngological Societies, 13005 Paris, France.
Audiol Res. 2024 Dec 20;14(6):1126-1135. doi: 10.3390/audiolres14060093.
: to retrospectively evaluate the clinical relevance of the 1000/500 Hz inter-frequency amplitude ratio (IFAR) in cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) in patients with unilateral definite Ménière's disease (MD) to identify the pathological ear. : cVEMPs and oVEMPs results obtained at 500 Hz and 1000 Hz were retrospectively analyzed in 28 patients with unilateral definite MD. 1000/500 Hz IFAR were calculated and compared for each ear. Spearman correlation tests between patient age and 1000/500 Hz IFAR were also performed. : No significant difference was observed between the 1000/500 Hz IFAR calculated in both pathological and healthy ears when the cVEMPs were performed ( = 0.74; Wilcoxon signed-rank test). 1000/500 Hz IFAR results obtained in healthy and pathological ears were also not different for oVEMPs ( = 0.73; Wilcoxon signed-rank test). Analysis of modified 1000/500 Hz IFARs for healthy and pathological ears showed no difference in both cVEMPs and oVEMPs ( = 0.44; = 0.95, respectively; Wilcoxon signed-rank test). There was a significant positive correlation between IFARs, modified IFARs, and patient age for cVEMPs ( = 0.017; = 0.012, respectively, Spearman's correlation test). A significant positive correlation was also found between modified IFARs and the subject age in oVEMPs ( = 0.019, Spearman's correlation test). : We did not observe any significant increase of 1000/500 Hz IFARs and 1000/500 Hz modified IFARs in ears affected by definite MD compared to healthy ears. Moreover, our research suggests that the age of the participants may influence IFAR results, which may lead to misdiagnosis in the elderly. It is, therefore, essential to conduct further prospective studies in larger cohorts, stratifying results by participant age, to better understand the role of 1000/500 Hz IFAR values in the diagnosis of MD.
回顾性评估单侧确诊梅尼埃病（MD）患者颈性和眼性前庭诱发肌源性电位（cVEMPs和oVEMPs）中1000/500 Hz频率间振幅比（IFAR）的临床相关性，以确定患耳。对28例单侧确诊MD患者在500 Hz和1000 Hz时获得的cVEMPs和oVEMPs结果进行回顾性分析。计算并比较每只耳朵的1000/500 Hz IFAR。还进行了患者年龄与1000/500 Hz IFAR之间的Spearman相关性检验。进行cVEMPs检查时，患耳和健耳计算出的1000/500 Hz IFAR之间未观察到显著差异（P = 0.74；Wilcoxon符号秩检验）。oVEMPs检查时，健耳和患耳的1000/500 Hz IFAR结果也无差异（P = 0.73；Wilcoxon符号秩检验）。对健耳和患耳的改良1000/500 Hz IFAR分析显示，cVEMPs和oVEMPs均无差异（分别为P = 0.44；P = 0.95；Wilcoxon符号秩检验）。cVEMPs的IFAR、改良IFAR与患者年龄之间存在显著正相关（分别为P = 0.017；P = 0.012，Spearman相关性检验）。oVEMPs的改良IFAR与受试者年龄之间也发现显著正相关（P = 0.019，Spearman相关性检验）。与健耳相比，我们未观察到确诊MD患耳的1000/500 Hz IFAR和1000/500 Hz改良IFAR有任何显著增加。此外，我们的研究表明，参与者的年龄可能会影响IFAR结果，这可能导致老年患者误诊。因此，有必要在更大的队列中进行进一步的前瞻性研究，按参与者年龄对结果进行分层，以更好地了解1000/500 Hz IFAR值在MD诊断中的作用。
