Shimizu Yuji, Yoshida Tomokatsu, Ito Keiko, Terada Kumiko, Sasaki Nagisa, Honda Eiko, Motomura Kazushi
Epidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka 537-0025, Japan.
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Diseases. 2024 Nov 28;12(12):305. doi: 10.3390/diseases12120305.
BACKGROUND/OBJECTIVES: Sleep disorders, such as short sleep, are common comorbidities in individuals with autism spectrum disorder (ASD). Sleep quality and duration are directly associated with quality of life (QOL). Clarifying the influence of ASD on the association between short sleep duration and life satisfaction is an efficient way to improve the QOL of patients with ASD.
To clarify the influence of ASD on the association between short sleep duration and life satisfaction scale scores, we conducted a web-based cross-sectional study involving 3823 Japanese adults aged 20-64 years.
In all the participants, a significant inverse association was observed between short sleep duration and life satisfaction. The adjusted odds ratio (OR) and 95% confidence interval (CI) of short sleep for one standard deviation (SD), the increment of life satisfaction scale (2.5 for men and 2.4 for women), was 0.76 (0.70, 0.82). When the analyses were stratified by ASD status, a significant inverse association was observed only among participants without ASD. The corresponding ORs (95% CIs) were 0.73 (0.67, 0.80) and 1.08 (0.85, 1.39) for those with and without ASD. Patients with ASD also showed a significant interaction effect on the association between short sleep duration and life satisfaction.
Only participants without ASD showed a significant inverse association between short sleep duration and life satisfaction. Although further investigations are necessary, these results can help clarify the mechanism underlying the association between QOL, short sleep duration, and ASD.
背景/目的：睡眠障碍，如睡眠不足，是自闭症谱系障碍（ASD）患者常见的合并症。睡眠质量和时长与生活质量（QOL）直接相关。阐明ASD对短睡眠时长与生活满意度之间关联的影响，是提高ASD患者生活质量的有效途径。
为阐明ASD对短睡眠时长与生活满意度量表得分之间关联的影响，我们开展了一项基于网络的横断面研究，纳入了3823名年龄在20至64岁之间的日本成年人。
在所有参与者中，观察到短睡眠时长与生活满意度之间存在显著的负相关。短睡眠时长每增加一个标准差（SD），生活满意度量表得分（男性增加2.5分，女性增加2.4分）的调整优势比（OR）和95%置信区间（CI）为0.76（0.70，0.82）。按ASD状态分层分析时，仅在无ASD的参与者中观察到显著的负相关。有ASD和无ASD参与者的相应OR（95%CI）分别为0.73（0.67，0.80）和1.08（0.85，1.39）。ASD患者在短睡眠时长与生活满意度之间的关联上也表现出显著的交互作用。
只有无ASD的参与者在短睡眠时长与生活满意度之间显示出显著的负相关。尽管还需要进一步研究，但这些结果有助于阐明生活质量、短睡眠时长和ASD之间关联的潜在机制。
