Wang Zexi, Zhang Zhiyi, Xu Changqing
School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4L8, Canada.
Quantum and Nanotechnologies Research Center, National Research Council Canada, Ottawa, ON K1A 0R6, Canada.
Biosensors (Basel). 2024 Nov 24;14(12):569. doi: 10.3390/bios14120569.
Free-standing capillary microfluidic channels were directly printed over printed electrodes using a particle/polymer mixture to fabricate microfluidic-electrochemical devices on polyethylene terephthalate (PET) films. Printed devices with no electrode modification were demonstrated to have the lowest limit of detection (LOD) of 7 μM for sensing glucose. The study shows that both a low polymer concentration in the mixture for printing the microfluidic channels and surface modification of the printed microfluidic channels using 3-aminopropyltrimethoxysilane can substantially boost the device's performance. It also shows that both device structure and enzyme doping level of the devices play an important role in ensuring the best performance of the devices under various testing conditions.
使用颗粒/聚合物混合物将独立式毛细管微流控通道直接印刷在印刷电极上，以在聚对苯二甲酸乙二醇酯（PET）薄膜上制造微流控电化学装置。结果表明，未进行电极修饰的印刷装置对葡萄糖传感的最低检测限（LOD）为7 μM。研究表明，用于印刷微流控通道的混合物中低聚合物浓度以及使用3-氨丙基三甲氧基硅烷对印刷微流控通道进行表面修饰，均可大幅提高装置性能。研究还表明，装置结构和装置的酶掺杂水平在确保装置在各种测试条件下的最佳性能方面都起着重要作用。
