Rabal-Soláns Ana, Mediero-Pérez Carmen, Yáñez-Vico Rosa M
School of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain.
BIOCRAN, Craniofacial Biology and Orthodontics Research Group, School of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain.
J Pers Med. 2024 Nov 29;14(12):1127. doi: 10.3390/jpm14121127.
: This systematic review and meta-analysis aimed to investigate the effects of presurgical orthopedics (PSO) on maxillary arch dimensions in infants with cleft lip and palate during the first year of life. : The review was conducted following PRISMA guidelines. A comprehensive electronic search was performed in MEDLINE, Embase, Cochrane, Scopus, and Google Scholar databases, supplemented by manual searching. Two reviewers independently conducted study selection, data extraction, quality assessment, and risk of bias evaluation. : Five studies were included in the meta-analysis. Quantitative analysis was performed based on the primary outcomes. The estimate was calculated using a random-effects model and z distribution (95% confidence interval (CI)). The results showed similar alveolar cleft widths (mean difference, -3.06; 95% CI, -8.03 to 2.70, = 0.30, I2 = 99%) with clinical differences in favor of PSO, and comparable posterior cleft widths (mean difference, -0.88; 95% CI, -2.06 to 0.30, = 0.14, I2 = 89%) with and without PSO in CLP babies. : This meta-analysis found no statistically significant effects of presurgical orthopedic treatment on maxillary arch dimensions in infants with cleft lip and palate during the first year of life. Further high-quality randomized controlled trials are needed to definitively establish the efficacy of PSO.
本系统评价和荟萃分析旨在研究术前正畸（PSO）对唇腭裂婴儿出生后第一年上颌牙弓尺寸的影响。本评价按照PRISMA指南进行。在MEDLINE、Embase、Cochrane、Scopus和谷歌学术数据库中进行了全面的电子检索，并辅以手工检索。两名评价者独立进行研究选择、数据提取、质量评估和偏倚风险评估。五项研究纳入了荟萃分析。基于主要结局进行了定量分析。使用随机效应模型和z分布（95%置信区间（CI））计算估计值。结果显示，牙槽裂宽度相似（平均差，-3.06；95%CI，-8.03至2.70，P = 0.30，I² = 99%），临床差异有利于PSO；唇腭裂婴儿术前正畸组和非术前正畸组的后腭裂宽度相当（平均差，-0.88；95%CI，-2.06至0.30，P = 0.14，I² = 89%）。本荟萃分析发现，术前正畸治疗对唇腭裂婴儿出生后第一年的上颌牙弓尺寸没有统计学上的显著影响。需要进一步开展高质量的随机对照试验来明确术前正畸的疗效。
