Wacker Julie, Farpour-Lambert Nathalie J, Viallon Magalie, Didier Dominique, Beghetti Maurice, Maggio Albane B R
Pediatric Cardiology Unit, Service of Pediatric Specialties, Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 1211 Geneva 14, Switzerland.
Obesity Prevention and Care Center Contrepoids, Service of Endocrinology, Diabetology, Nutrition and Therapeutic Patient Education, Department of Medicine, University Hospital of Geneva and University of Geneva, 1211 Geneva 14, Switzerland.
J Cardiovasc Dev Dis. 2024 Nov 29;11(12):383. doi: 10.3390/jcdd11120383.
: In adults, epicardial adipose tissue (EAT) is associated with metabolic syndrome (MS) and coronary artery disease. EAT thickness is increased in obese youth, but total EAT volume and its correlation with cardiovascular risk factors have not been studied. : To determine EAT volume in adolescents and its association with obesity and cardiovascular risk factors. We performed a cross-sectional study including 48 pubertal adolescents (24 obese and 24 lean subjects, aged 13.6 ± 1.5 yr). EAT volume as well as visceral and subcutaneous abdominal adipose tissue volumes were obtained by magnetic resonance imaging. Anthropometrical parameters; blood pressure (BP); fasting serum triglycerides; total and low- and high-density lipoprotein (HDL-C) cholesterol; glucose; and insulin levels were measured. : Obese adolescents had higher EAT volume compared to lean controls (49.6 ± 18.0 vs. 17.6 ± 6.7 cm, < 0.0005). They also had significantly increased visceral abdominal fat volumes, systolic BP, serum triglycerides, and insulin levels, and decreased HDL-C concentration. EAT volume was significantly associated with anthropometrical indices and cardiovascular risk factors: waist circumference, systolic BP, triglycerides, HDL-C levels, and insulin resistance indices. Metabolic syndrome was present in 25% of obese adolescents. EAT volume was significantly higher in obese adolescents with MS compared to those without MS (63.5 ± 21.4 vs. 44.9 ± 14.6 cm, = 0.026). : EAT volume, which is known to contribute to atherogenesis in adults, is increased in obese adolescents, and is associated with abdominal visceral fat, cardiovascular risk factors, and MS. Excessive EAT early in life may contribute to the development of premature cardiometabolic disease.
在成年人中，心外膜脂肪组织（EAT）与代谢综合征（MS）及冠状动脉疾病相关。肥胖青少年的EAT厚度增加，但EAT总体积及其与心血管危险因素的相关性尚未得到研究。
确定青少年的EAT体积及其与肥胖和心血管危险因素的关联。我们进行了一项横断面研究，纳入48名青春期青少年（24名肥胖和24名瘦受试者，年龄13.6±1.5岁）。通过磁共振成像获得EAT体积以及腹部内脏和皮下脂肪组织体积。测量人体测量参数、血压（BP）、空腹血清甘油三酯、总胆固醇以及低密度和高密度脂蛋白（HDL-C）胆固醇、血糖和胰岛素水平。
与瘦对照组相比，肥胖青少年的EAT体积更高（49.6±18.0 vs. 17.6±6.7 cm³，P<0.0005）。他们的腹部内脏脂肪体积、收缩压、血清甘油三酯和胰岛素水平也显著增加，而HDL-C浓度降低。EAT体积与人体测量指标和心血管危险因素显著相关：腰围、收缩压、甘油三酯、HDL-C水平和胰岛素抵抗指数。25%的肥胖青少年存在代谢综合征。与无MS的肥胖青少年相比，患有MS的肥胖青少年的EAT体积显著更高（63.5±21.4 vs. 44.9±14.6 cm³，P = 0.026）。
已知在成年人中有助于动脉粥样硬化形成的EAT体积在肥胖青少年中增加，并且与腹部内脏脂肪、心血管危险因素和MS相关。生命早期EAT过多可能导致过早发生心脏代谢疾病。
