Izzo Carmine, Visco Valeria, Cirillo Alessandra, Bonadies Davide, Caliendo Giuseppe, Rusciano Maria Rosaria, Virtuoso Nicola, Loria Francesco, Bramanti Alessia, Venturini Eleonora, Di Pietro Paola, Pilone Vincenzo, Schiavo Luigi, Carrizzo Albino, Vecchione Carmine, Ciccarelli Michele
Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy.
Cardiology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84081 Salerno, Italy.
J Cardiovasc Dev Dis. 2024 Dec 3;11(12):389. doi: 10.3390/jcdd11120389.
Severe obesity is closely associated with an increased risk of comorbidities and alterations in cardiac structure and function. The primary objective of this study was to investigate cardiovascular (CV) risk factors and ventricular remodeling in individuals from an obese population eligible for bariatric surgery. The secondary objective was to evaluate changes in anthropometric, clinical laboratory, and echocardiographic measurements 12 weeks after surgery compared to baseline values. This retrospective observational cohort study involved patients from a single specialized bariatric surgery center. A total of 35 patients were included (mean age 41.5 ± 10.3 years; BMI 43.4 ± 6.6 kg/m), of whom 34.2% had a family history of coronary artery disease (CAD), 5.7% had a prior history of CAD, 8 had essential hypertension, 11.4% had dyslipidemia, 20% were smokers, and 8.6% were former smokers. Approximately 57% of the patients exhibited concentric left ventricular remodeling, and 14% had grade I diastolic dysfunction. At 12 weeks post-surgery, with an average weight loss of 25 kg and a mean BMI reduction of 8.5 kg/m, 14% of the patients still exhibited concentric left ventricular remodeling, and about 11% had grade I diastolic dysfunction. Bariatric surgery contributes to the improvement of cardiac function and structure over time as a result of significant weight loss.
重度肥胖与合并症风险增加以及心脏结构和功能改变密切相关。本研究的主要目的是调查符合减肥手术条件的肥胖人群的心血管(CV)危险因素和心室重塑情况。次要目的是评估术后12周时人体测量学、临床实验室检查和超声心动图测量结果相对于基线值的变化。这项回顾性观察队列研究纳入了来自单一专业减肥手术中心的患者。共纳入35例患者(平均年龄41.5±10.3岁;BMI 43.4±6.6kg/m²),其中34.2%有冠状动脉疾病(CAD)家族史,5.7%有CAD既往史,8例有原发性高血压,11.4%有血脂异常,20%为吸烟者,8.6%为既往吸烟者。约57%的患者表现为同心性左心室重塑,14%有I级舒张功能障碍。术后12周时,平均体重减轻25kg,平均BMI降低8.5kg/m²,14%的患者仍表现为同心性左心室重塑,约11%有I级舒张功能障碍。减肥手术由于显著的体重减轻,随着时间的推移有助于心脏功能和结构的改善。