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5-氮杂胞苷对红曲中莫纳可林K及色素产量的提高作用

Improvement of Monacolin K and Pigment Production in by 5-Azacytidine.

作者信息

Zhang Chan, Wang Haijiao, Sun Qing, Ablimit Arzugul, Dong Huijun, Wang Congcong, Zhai Duchen, Zhang Bobo, Hu Wenlin, Liu Chengjian, Wang Chengtao

机构信息

School of Food and Health, Beijing Technology & Business University (BTBU), Beijing 100048, China.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University (BTBU), Beijing 100048, China.

出版信息

J Fungi (Basel). 2024 Nov 26;10(12):819. doi: 10.3390/jof10120819.

DOI:10.3390/jof10120819
PMID:39728315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676827/
Abstract

species are known to produce various secondary metabolites with polyketide structures, including Monacolins, pigments, and citrinin. This study investigates the effects of 5-azacytidine on M1 and RP2. The dry weight, red, yellow, and orange pigment values, and Monacolin K yield of both strains were measured, and their hyphae observed through electron microscopy. The experimental group showed higher dry weights and pigment values than the control group for both strains. However, Monacolin K production increased substantially only for M1. Electron micrographs revealed surface wrinkles and large protrusions in both strains after 5-azacytidine treatment. As a potent DNA methylation-promoting agent, 5-azacytidine is very useful for epigenetic and cancer biology studies and for studying secondary metabolism in fungi.

摘要

已知某些物种会产生具有聚酮结构的各种次生代谢产物，包括莫纳可林、色素和桔霉素。本研究调查了5-氮杂胞苷对M1和RP2的影响。测量了两种菌株的干重、红色、黄色和橙色色素值以及莫纳可林K产量，并通过电子显微镜观察了它们的菌丝。实验组的两种菌株的干重和色素值均高于对照组。然而，仅M1的莫纳可林K产量大幅增加。电子显微镜照片显示，5-氮杂胞苷处理后两种菌株的表面出现皱纹和大的突起。作为一种有效的DNA甲基化促进剂，5-氮杂胞苷对于表观遗传学和癌症生物学研究以及真菌次生代谢研究非常有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/ef580a02f581/jof-10-00819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/584033041f38/jof-10-00819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/34000414b1d4/jof-10-00819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/b24a360efbc9/jof-10-00819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/f201fb8c1cb2/jof-10-00819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/ef580a02f581/jof-10-00819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/584033041f38/jof-10-00819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/34000414b1d4/jof-10-00819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/b24a360efbc9/jof-10-00819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/f201fb8c1cb2/jof-10-00819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffc6/11676827/ef580a02f581/jof-10-00819-g005.jpg

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本文引用的文献

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Fungal Genet Biol. 2021 Jun;151:103564. doi: 10.1016/j.fgb.2021.103564. Epub 2021 May 5.
2
Overexpression of global regulator LaeA increases secondary metabolite production in Monascus purpureus.LaeA 全局调控因子过表达增加红曲菌中次级代谢产物的生成。
Appl Microbiol Biotechnol. 2020 Apr;104(7):3049-3060. doi: 10.1007/s00253-020-10379-4. Epub 2020 Feb 11.
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A Comprehensive Analysis of the Small GTPases Ypt7 Involved in the Regulation of Fungal Development and Secondary Metabolism in M7.
参与调控米曲霉发育及次级代谢的小GTP酶Ypt7的综合分析
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Effects of 5-Azacytidine on Growth and Hypocrellin Production of .5-氮杂胞苷对……生长及竹红菌素产生的影响
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The DNA-methyltransferase inhibitor 5-aza-2-deoxycytidine affects Humicola grisea enzyme activities and the glucose-mediated gene repression.DNA-甲基转移酶抑制剂 5-氮杂-2-脱氧胞苷影响嗜热毁丝霉酶活性和葡萄糖介导的基因阻遏。
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Biological evaluation of novel derivatives of the orange pigments from Monascus sp. as inhibitors of melanogenesis.红曲霉菌橙色色素新型衍生物作为黑色素生成抑制剂的生物学评价
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