Söylemez Esra, Sağol Sermet
Department of Obstetrics and Gynecology, Mardin Education and Research Hospital, Mardin 47100, Turkey.
Department of Perinatology, Ege University, İzmir 35000, Turkey.
Med Sci (Basel). 2024 Dec 14;12(4):73. doi: 10.3390/medsci12040073.
This study aims to investigate the possible effects of gestational diabetes mellitus (GDM) on fetal heart structure and the relationship of this effect with maternal blood sugar control.
In this cross-sectional study, 19 women with GDM at 24-36 weeks of gestation (case group) and 21 healthy pregnant women at the same weeks of gestation (control group) were examined. Fetal heart structure was evaluated by ultrasonography; interventricular septum (IVS) thickness, right and left ventricular sphericity indices, global sphericity index (GSI) and cardio-thoracic ratio were also measured. In addition, mothers' HbA1c values (an indicator of blood sugar control) were recorded.
An increase in IVS thickness was observed in the fetuses of mothers with GDM. A more rounded trend was observed in the right ventricular structure, but this did not create a significant difference. No significant relationship was found between maternal blood sugar control and fetal heart structure.
This study examined the effects of gestational diabetes on fetal cardiac morphology and the relationship of this effect with maternal glycemic control. Babies of mothers with GDM had a significantly thicker interventricular septum. A more rounded trend was detected in the right ventricular structure. However, this change was not found to be statistically significant. In addition, no significant correlation was found between maternal glycemic control and fetal cardiac morphology.
本研究旨在探讨妊娠期糖尿病（GDM）对胎儿心脏结构的可能影响以及这种影响与母亲血糖控制之间的关系。
在这项横断面研究中，对19例妊娠24 - 36周的GDM孕妇（病例组）和21例同期妊娠的健康孕妇（对照组）进行了检查。通过超声心动图评估胎儿心脏结构；还测量了室间隔（IVS）厚度、左右心室球形指数、整体球形指数（GSI）和心胸比。此外，记录母亲的糖化血红蛋白（HbA1c）值（血糖控制指标）。
观察到GDM孕妇胎儿的IVS厚度增加。右心室结构呈现出更圆钝的趋势，但这并未产生显著差异。未发现母亲血糖控制与胎儿心脏结构之间存在显著关系。
本研究考察了妊娠期糖尿病对胎儿心脏形态的影响以及这种影响与母亲血糖控制的关系。GDM孕妇的婴儿室间隔明显增厚。右心室结构检测到更圆钝的趋势。然而，这种变化在统计学上并不显著。此外，未发现母亲血糖控制与胎儿心脏形态之间存在显著相关性。
