Sharma Anuj, Nayak Arpita, Ghaisas Shamika, Vidya K
Department of Ophthalmology, Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthigram, Andhra Pradesh, India.
Indian J Ophthalmol. 2025 Mar 1;73(Suppl 2):S221-S225. doi: 10.4103/IJO.IJO_1434_24. Epub 2024 Dec 27.
To assess the effectiveness of selective laser trabeculoplasty (SLT) in Indian eyes with open-angle glaucoma (OAG).
Single-center, prospective, interventional study.
Patients undergoing SLT from January 2014 to June 2018 for OAG were included in the study. Treatment-naive naive as well as patients on antiglaucoma medications (AGM) with suboptimal intraocular pressure (IOP) control were included. The main outcome measure was the percentage reduction in IOP. Complete success was defined as IOP reduction > 20% from baseline after 12 months or reduction in the number of AGM. Qualified success was defined as > 20% IOP reduction at 12 months with AGM. Secondary outcomes were occurrence of adverse events and factors predicting treatment outcomes.
A total of 104 eyes of 62 Indian patients underwent SLT for OAG. Eighty-three (79.81%) eyes were treatment-naïve, and 21 (20.19%) eyes were on AGM. The median (IQR) baseline IOP was 20 (16-26) mmHg. At 12 months, the median IOP was 16 (4-19) mmHg, the median decrease in IOP was 4 (0-6.5) mmHg, and the percentage reduction in IOP was 17.42% (0%-30.76%). Maximum IOP reduction was noted at 12 months. Overall, success was achieved in 48 (46.15%) patients. Five eyes (4.8%) experienced minor SLT-related complications. Age, gender, prior use of AGM, type of OAG, and higher baseline IOP were not found to be predictive factors for treatment outcome.
SLT was found to be a relatively safe and effective procedure in Indian eyes with OAG.
评估选择性激光小梁成形术（SLT）治疗印度开角型青光眼（OAG）患者的有效性。
单中心、前瞻性、干预性研究。
纳入2014年1月至2018年6月期间因OAG接受SLT治疗的患者。包括未经治疗的初治患者以及眼压（IOP）控制不佳的青光眼药物（AGM）治疗患者。主要观察指标为IOP降低的百分比。完全成功定义为12个月后IOP较基线降低>20%或AGM数量减少。合格成功定义为12个月时使用AGM情况下IOP降低>20%。次要观察指标为不良事件的发生情况以及预测治疗结果的因素。
62例印度患者的104只眼睛因OAG接受了SLT治疗。83只（79.81%）眼睛为初治，21只（20.19%）眼睛正在接受AGM治疗。基线IOP的中位数（四分位间距）为20（16 - 26）mmHg。12个月时，IOP中位数为16（4 - 19）mmHg，IOP中位数降低4（0 - 6.5）mmHg，IOP降低百分比为17.42%（0% - 30.76%）。IOP在12个月时降低最多。总体而言，48例（46.15%）患者取得成功。5只眼睛（4.8%）出现了与SLT相关的轻微并发症。年龄、性别、既往使用AGM情况、OAG类型以及较高的基线IOP未被发现是治疗结果的预测因素。
在印度OAG患者眼中，SLT被发现是一种相对安全有效的手术。
