Gomes Cristiane Tiburtino de Oliveira, Mariz Carolline Araujo, Batista Andrea Dória, Morais Clarice Neuenschwander Lins de, Araújo Lílian, Sá Barreto Ana Virgínia Matos, Gomes-Gouvêa Michele Soares, Domingues Ana Lúcia, Lopes Edmundo Pessoa
Postgraduate Program in Tropical Medicine, Center of Medical Sciences, Universidade Federal de Pernambuco (UFPE), Recife 50670-420, PE, Brazil.
Department of Parasitology, Aggeu Magalhães Institute, Fiocruz, Recife 50740-465, PE, Brazil.
Trop Med Infect Dis. 2024 Dec 20;9(12):310. doi: 10.3390/tropicalmed9120310.
The occurrence of hepatitis E virus (HEV) in patients with Schistosomiasis mansoni (SM) is still poorly understood in Brazil. The objective of this study was to estimate the seroprevalence of anti-HEV IgG in patients with SM and its association with the periportal fibrosis (PPF), assessed by serum markers and ultrasound criteria. This cross-sectional study was carried out in an endemic area in Pernambuco, Brazil, with schistosomal patients who underwent coproscopic survey. Anti-HEV antibody IgG were evaluated by using ELISA (Euroimmun Lübeck, Germmany). In positive cases, HEV-RNA was tested by using real-time PCR. Among the 286 patients (60.8% women; 56% 18-44 years), 116 (40.6%) had advanced PPF (Niamey pattern D/E/F). Anti-HEV IgG was positive in 15 (5.24%), and all were HEV-RNA negative. Anti-HEV IgG was more frequent in patients with an advanced PPF (D/E/F) pattern ( = 0.034) and those with the largest spleen diameter ( = 0.039). In this study, the occurrence of anti-HEV IgG in patients with SM was higher than described in the same region and more frequent among patients with evidence of advanced liver fibrosis.
在巴西，曼氏血吸虫病（SM）患者中戊型肝炎病毒（HEV）的感染情况仍未得到充分了解。本研究的目的是通过血清标志物和超声标准评估，估计SM患者中抗HEV IgG的血清流行率及其与门静脉周围纤维化（PPF）的关联。这项横断面研究在巴西伯南布哥州的一个流行地区对接受粪便检查的血吸虫病患者进行。使用酶联免疫吸附测定法（ELISA，德国吕贝克欧蒙公司）评估抗HEV抗体IgG。在阳性病例中，采用实时聚合酶链反应检测HEV-RNA。在286名患者中（60.8%为女性；56%年龄在18 - 44岁），116名（40.6%）患有晚期PPF（尼亚美模式D/E/F）。15名（5.24%）患者的抗HEV IgG呈阳性，且所有患者的HEV-RNA均为阴性。抗HEV IgG在晚期PPF（D/E/F）模式患者（P = 0.034）和脾脏直径最大的患者中（P = 0.039）更为常见。在本研究中，SM患者中抗HEV IgG的发生率高于同一地区的描述，且在有晚期肝纤维化证据的患者中更为常见。
