Bortoliero André Luiz, Bonametti Ana Maria, Morimoto Helena Kaminami, Matsuo Tiemi, Reiche Edna Maria Vissoci
Department of Internal Medicine, Health Sciences Center, Londrina State University, Londrina, Paraná, Brazil.
Rev Inst Med Trop Sao Paulo. 2006 Mar-Apr;48(2):87-92. doi: 10.1590/s0036-46652006000200006. Epub 2006 May 8.
A cross-sectional study was carried out among 996 volunteer blood donors enrolled from May 1999 to December 1999 to determine the seroprevalence of hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, Brazil, and to evaluate whether the rate of seroprevalence of IgG anti-HEV antibodies is associated with sociodemographic variables and with seropositivity for hepatitis A virus (HAV) infection. All participants answered the questionnaire regarding the sociodemographic characteristics. Serum samples were tested for IgG antibodies to HEV (anti-HEV) by an enzyme linked immunoassay (ELISA). All serum samples positive for anti-HEV IgG and 237 serum samples negative for anti-HEV were also assayed for IgG anti-HAV antibodies by ELISA. Anti-HEV IgG was confirmed in 23/996 samples, resulting in a seroprevalence of 2.3% for HEV infection, similar to previous results obtained in developed countries. No significant association was found between the presence of anti-HEV IgG antibodies and the sociodemographic variables including gender, age, educational level, rural or urban areas, source of water, and sewer system (p > 0.05). Also, no association with seropositivity for anti-HAV IgG antibodies was observed (p > 0.05). Although this study revealed a low seroprevalence of HEV infection in the population evaluated, the results showed that this virus is circulating among the population from Londrina, South Brazil, and point out the need of further studies to define the clinical and epidemiological importance of HEV infection and to identify additional risk factors involved in the epidemiology and pathogenesis of this infection in this population.
1999年5月至1999年12月期间，对996名自愿献血者进行了一项横断面研究，以确定巴西巴拉那州隆德里纳地区血库的自愿献血者中戊型肝炎病毒（HEV）感染的血清流行率，并评估抗HEV IgG抗体的血清流行率是否与社会人口统计学变量以及甲型肝炎病毒（HAV）感染的血清阳性率相关。所有参与者都回答了关于社会人口统计学特征的问卷。通过酶联免疫吸附测定（ELISA）检测血清样本中的抗HEV IgG抗体。所有抗HEV IgG阳性的血清样本和237份抗HEV阴性的血清样本也通过ELISA检测抗HAV IgG抗体。在996份样本中有23份抗HEV IgG得到确认，导致HEV感染的血清流行率为2.3%，这与发达国家先前获得的结果相似。在抗HEV IgG抗体的存在与包括性别、年龄、教育水平、农村或城市地区、水源和下水道系统在内的社会人口统计学变量之间未发现显著关联（p>0.05）。此外，也未观察到与抗HAV IgG抗体血清阳性率的关联（p>0.05）。尽管这项研究显示在所评估的人群中HEV感染的血清流行率较低，但结果表明该病毒正在巴西南部隆德里纳的人群中传播，并指出需要进一步研究以确定HEV感染的临床和流行病学重要性，并确定该人群中这种感染的流行病学和发病机制中涉及的其他风险因素。
