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微量元素和维生素对牦牛卵泡颗粒细胞甾体激素合成的影响

Effects of Trace Elements and Vitamins on the Synthesis of Steroid Hormones in Follicular Granulosa Cells of Yak.

作者信息

Lou Yanbing, Yang Tingting, Zhu Yanqiu, Xia Chenglong, Cui Hengmin, Deng Huidan, Huang Yixin, Fang Jing, Zuo Zhicai, Guo Hongrui

机构信息

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.

出版信息

Vet Sci. 2024 Dec 3;11(12):619. doi: 10.3390/vetsci11120619.

DOI:10.3390/vetsci11120619
PMID:39728959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11680255/
Abstract

Yak (), a special breed of cattle on the Qinghai-Tibet Plateau, has low fertility due to nutritional deficiency, especially the trace elements. The steroid hormones estradiol (E2) and progesterone (P4) synthesized by yak follicular granulosa cells (BGCs) are involved in the entire reproductive process. In the present study, we investigated the effects of trace elements and vitamins on yak follicular GCs, including the cellular activity, the synthesis of E2 and P4, and the expression of genes related to steroid hormone synthesis. The results showed that moderate supplementation of vitamin D3 (VD3), strontium (Sr), manganese (Mn), and selenium (Se) enhanced granulosa cell activity. Within the safe dose range, the addition of vitamin A (VA), VD3, cobalt (Co), Sr, copper (Cu), Mn, Se, and chromium (Cr) significantly increased the synthesis of E2 by GCs, while the addition of VA, vitamin C (VC), VE, zinc (Zn), Sr, Cu, and Cr enhanced the production of P4 in GCs. The changes in steroid synthesizing genes were consistent with the changes in hormone synthesis. This study provides an experimental basis for the addition of trace elements to improve the production performance of yaks.

摘要

牦牛是青藏高原特有的牛种，由于营养缺乏，尤其是微量元素缺乏，其繁殖力较低。牦牛卵泡颗粒细胞（BGCs）合成的类固醇激素雌二醇（E2）和孕酮（P4）参与整个生殖过程。在本研究中，我们研究了微量元素和维生素对牦牛卵泡颗粒细胞的影响，包括细胞活性、E2和P4的合成以及与类固醇激素合成相关基因的表达。结果表明，适量补充维生素D3（VD3）、锶（Sr）、锰（Mn）和硒（Se）可增强颗粒细胞活性。在安全剂量范围内，添加维生素A（VA）、VD3、钴（Co）、Sr、铜（Cu）、Mn、Se和铬（Cr）可显著增加颗粒细胞合成E2，而添加VA、维生素C（VC）、VE、锌（Zn）、Sr、Cu和Cr可增强颗粒细胞中P4的产生。类固醇合成基因的变化与激素合成的变化一致。本研究为添加微量元素提高牦牛生产性能提供了实验依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/43be5e4295a0/vetsci-11-00619-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/c939c9adf113/vetsci-11-00619-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/2b51112e42e9/vetsci-11-00619-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/03b8c3800c91/vetsci-11-00619-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/9d5e4c817529/vetsci-11-00619-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/43be5e4295a0/vetsci-11-00619-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/c939c9adf113/vetsci-11-00619-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/5e84a4d8462a/vetsci-11-00619-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/2b51112e42e9/vetsci-11-00619-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/9d5e4c817529/vetsci-11-00619-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e2/11680255/43be5e4295a0/vetsci-11-00619-g007.jpg

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