Research Unit of Clinical Medicine, University of Oulu, 90014 Oulu, Finland.
Medical Research Center, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland.
Nutrients. 2023 May 29;15(11):2522. doi: 10.3390/nu15112522.
Infertility and fecundability problems have been linked with lower 25-hydroxyvitamin D (25(OH)D) concentrations, but studies conducted with small, heterogenous or selected populations have shown inconsistent results.
This study included women at age 31 from prospective population-based Northern Finland Birth Cohort 1966. Serum 25(OH)D concentrations were evaluated between women with or without previous infertility examinations or treatments (infertility group, = 375, reference group, = 2051) and time to pregnancy (TTP) of over 12 months (decreased fecundability group, = 338) with a wide range of confounders. Furthermore, 25(OH)D concentrations were also compared among reproductive outcomes.
The mean 25(OH)D concentration was lower and 25(OH)D < 30 nmol/L was more frequent in women with a history of infertility compared to reference group. Moreover, 25(OH)D > 75 nmol/L was more frequent in the reference group. The mean 25(OH)D concentration was lower in women who had had multiple miscarriages. Both history of infertility (β = -2.7, 95% confidence interval (CI) -4.6, -0.7) and decreased fecundability associated with lower 25(OH)D concentration (β = -4.1, 95% CI -7.4, -0.8) after adjustments. In conclusion, this population-based study demonstrated that previous infertility and decreased fecundability were associated with lower 25(OH)D.
不孕和生育能力问题与较低的 25-羟维生素 D（25（OH）D）浓度有关，但基于小样本、异质或选择性人群的研究结果不一致。
本研究纳入了年龄在 31 岁的前瞻性基于人群的芬兰北部出生队列 1966 年的女性。在有或没有既往不孕检查或治疗史的女性（不孕组，n=375，对照组，n=2051）和 12 个月以上妊娠时间（生育能力下降组，n=338）之间，评估血清 25（OH）D 浓度，并考虑了广泛的混杂因素。此外，还比较了 25（OH）D 浓度与生殖结局之间的关系。
与对照组相比，有不孕史的女性平均 25（OH）D 浓度较低，25（OH）D<30nmol/L 更为常见。此外，对照组中 25（OH）D>75nmol/L 的比例更高。有多次流产史的女性平均 25（OH）D 浓度较低。既往不孕（β=-2.7，95%置信区间（CI）-4.6，-0.7）和生育能力下降（β=-4.1，95%CI-7.4，-0.8）都与 25（OH）D 浓度降低有关，调整后差异有统计学意义。总之，本基于人群的研究表明，既往不孕和生育能力下降与 25（OH）D 浓度降低有关。
