Negoescu Andrada, Gal Claudiu, Mihaila Andrei, Mihaila Constantin, Cătoi Cornel, Taulescu Marian
Department of Anatomic Pathology, Faculty of Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Department of Veterinary Pathology, Synevovet, 81 Pache Protopopescu, 021408 Bucharest, Romania.
Vet Sci. 2024 Dec 7;11(12):632. doi: 10.3390/vetsci11120632.
Canine extraskeletal osteosarcomas are mesenchymal, osteoid producing tumors that can arise in soft tissues without initial involvement of the bones. An 8-year-old intact male Beagle dog presented with anorexia, abdominal pain, intermittent vomiting and melena. The patient had a history of recurrent ingestion of cotton based-toy fragments, but no prior surgical procedures involving the abdominal cavity. During the exploratory laparotomy, a mass was identified in the jejunal wall. Surgical resection was performed, and tissue samples were collected for pathological examination. Histologically, the mass was diagnosed as osteoblastic osteosarcoma with fragments of cotton fiber material. The neoplastic cells were immunolabeled for vimentin and BMP-2, further supporting the morphological diagnosis. Seven months after the surgery, metastatic nodules were identified in the liver. The dog died ten months after intestinal mass resection. This case represents the first documented instance of metastatic intestinal osteosarcoma potentially caused by ingestion of cotton fiber material.
犬骨骼外骨肉瘤是一种间充质、产生骨样组织的肿瘤，可发生于软组织，最初不累及骨骼。一只8岁未绝育的雄性比格犬出现厌食、腹痛、间歇性呕吐和黑便。该患者有反复摄入棉质玩具碎片的病史，但此前没有涉及腹腔的外科手术史。在剖腹探查术中，在空肠壁发现一个肿块。进行了手术切除，并采集组织样本进行病理检查。组织学上，该肿块被诊断为成骨性骨肉瘤，并伴有棉纤维材料碎片。肿瘤细胞经波形蛋白和骨形态发生蛋白-2免疫标记，进一步支持形态学诊断。术后7个月，在肝脏发现转移结节。这只狗在肠道肿块切除术后10个月死亡。该病例是首例有记录的可能由摄入棉纤维材料引起的转移性肠道骨肉瘤。
