Silver K I, Patkar S, Mazcko C, Berger E P, Beck J A, LeBlanc A K
Comparative Oncology Program, Molecular Imaging Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Artificial Intelligence Resource, Molecular Imaging Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Vet Comp Oncol. 2023 Dec;21(4):646-655. doi: 10.1111/vco.12927. Epub 2023 Aug 17.
Osteosarcoma is a highly metastatic primary bone tumour that occurs spontaneously in both pet dogs and humans. Patterns of metastasis to organs beyond the most common site (lung) are poorly characterised and it is unknown whether specific associations between patterns of metastatic progression and patient features exist. This retrospective study characterised the necropsy findings of 83 dogs receiving standardised therapy and clinical monitoring in a prospective clinical trial setting to document patterns of metastasis and correlate outcomes with these patterns and other patient and tumour-specific factors. A total of 20 different sites of metastasis were documented, with lung as the most common site, followed by bone, kidney, liver, and heart. Two distinct clusters of dogs were identified based on patterns of metastasis. There was no significant association between site of enrollment, trial arm, sex, serum alkaline phosphatase (ALP) activity, or tumour location and clinical outcomes. A second cancer type was identified at necropsy in 10 dogs (10/83; 12%). These data showcase the extensive nature of osteosarcoma metastasis beyond the lung and provide a benchmark for clinical monitoring of the disease. Further, this study provides insight into transcriptional features of primary tumours that may relate to a propensity for osteosarcoma metastasis to specific organs and tissues.
骨肉瘤是一种高度转移性的原发性骨肿瘤，在宠物狗和人类中均可自发发生。骨肉瘤转移至最常见转移部位（肺）以外器官的模式尚未得到充分描述，转移性进展模式与患者特征之间是否存在特定关联也尚不清楚。这项回顾性研究对83只在一项前瞻性临床试验中接受标准化治疗和临床监测的犬只的尸检结果进行了分析，以记录转移模式，并将结果与这些模式以及其他患者和肿瘤特异性因素相关联。共记录到20个不同的转移部位，其中肺是最常见的转移部位，其次是骨、肾、肝和心脏。根据转移模式确定了两组不同的犬只。入组部位、试验组、性别、血清碱性磷酸酶（ALP）活性、肿瘤位置与临床结果之间均无显著关联。尸检时在10只犬（10/83；12%）中发现了第二种癌症类型。这些数据展示了骨肉瘤转移至肺以外部位的广泛性，并为该疾病的临床监测提供了一个基准。此外，本研究还深入探讨了原发性肿瘤的转录特征，这些特征可能与骨肉瘤转移至特定器官和组织的倾向有关。
