Möller Leona, Jünemann Clara, Claudi Christian, Schramm Patrick
Klinik für Neurologie, Standort Marburg, Universitätsklinikum Gießen und Marburg, Marburg, Deutschland.
Neurologische Klinik, Standort Gießen, Universitätsklinikum Gießen und Marburg, Klinikstraße 33, 35392, Gießen, Deutschland.
Med Klin Intensivmed Notfmed. 2025 Mar;120(2):103-109. doi: 10.1007/s00063-024-01223-y. Epub 2024 Dec 27.
Epileptic seizures, which are often accompanied by a reduction in vigilance, are a common emergency. Every first-time epileptic seizure should be investigated further. Particular attention should be paid to whether it is an acute symptomatic seizure, which is an acute event characterized by a metabolic disorder or acute cerebral damage within a certain period of time, or possibly epilepsy. In terms of differential diagnosis, psychogenic nonepileptic seizures also pose a challenge, as they are often not easy to distinguish from epileptic seizures, but require a different therapeutic approach. Persistent epileptic seizures in the sense of status epilepticus (duration: > 5 min) are also common in the (pre)clinical emergency situation and require immediate initiation of adequate therapy, which consists of rapid and sufficient administration of benzodiazepines. Nasal administration is a quick and simple option here, particularly in the prehospital setting. Furthermore, persistent reductions in vigilance are a not infrequently occurring phenomenon in the (pre)clinical setting, which is, however, based on numerous differential diagnoses. Here, nonconvulsive status epilepticus should be considered as a possible cause and rapid diagnosis using EEG should be sought in order to begin early treatment, which improves patient outcomes.
癫痫发作常伴有警觉性降低,是一种常见的急症。每一次首次癫痫发作都应进一步检查。应特别注意其是否为急性症状性发作,这是一种在特定时间段内以代谢紊乱或急性脑损伤为特征的急性事件,或者是否可能为癫痫。在鉴别诊断方面,心因性非癫痫性发作也构成挑战,因为它们往往不易与癫痫发作区分开来,但需要不同的治疗方法。癫痫持续状态(持续时间:>5分钟)意义上的持续性癫痫发作在(临床)急诊情况下也很常见,需要立即开始适当治疗,包括快速足量给予苯二氮䓬类药物。在此,鼻内给药是一种快速简便的选择,尤其是在院前环境中。此外,警觉性持续降低在(临床)环境中并非罕见现象,然而,这基于众多鉴别诊断。在此,应考虑非惊厥性癫痫持续状态为可能原因,并应寻求通过脑电图进行快速诊断以便开始早期治疗,从而改善患者预后。