He Xiang, Shen Xiping, Yang Tingting, Ma Guifen, Nan Jinhan, Feng Juanjuan, Yan Fanghong, Wang Cuilian, Han Lin, Zhang Yanan, Ma Yuxia
Evidence-Based Nursing-Center, School of Nursing, Lanzhou University, 730010, No.28, West Yan Road, Chengguan District, Lanzhou, Gansu Province, China.
School of Public Health, Lanzhou University, Lanzhou, 730010, Gansu Province, China.
Neurosurg Rev. 2024 Dec 27;48(1):6. doi: 10.1007/s10143-024-03143-z.
Stroke is the second leading cause of death and the third-leading cause of disability in the world. The skeletal muscles play a key role in disability following stroke. Although many studies have reported the prevalence and risk factors of sarcopenia in patients with stroke, the results have not been synthesized. This systematic review was conducted to explore the prevalence and risk factors of sarcopenia in patients with stroke. PubMed, Embase, The Cochrane Library, Web of Science, Chinese Biomedical Literature (CBM), China National Knowledge Infrastructure (CNKI), Weipu Database (VIP), Wanfang Database were comprehensively searched for studies exploring the prevalence and risk factors of sarcopenia in patients with stroke from inception to October 5th, 2022. This review included 19 studies involving 4148 subjects. The total prevalence of sarcopenia in patients with stroke is 46% (95% confidence interval, CI: 40% to 52%, I = 94%, P < 0.001). Age (MD = 0.43, 95%CI: 0.06 to 0.81, I = 88.3%, P < 0.001), stroke duration (MD = 0.20, 95%CI: 0.05 to 0.34, I = 37.2%, P = 0.189), length of hospital stay (MD = 0.40, 95%CI: 0.20 to 0.59, I = 0, P = 0.393), pneumonia history (OR = 3.21, 95%CI: 1.98 to 5.20, I = 0, P = 0.343), female (OR = 1.36, 95%CI: 1.09 to 1.70, I = 48.7%, P = 0.069), albumin (MD = -0.43, 95%CI: -0.58 to -0.28, I = 13.7%, P < 0.001), hemoglobin (MD = -0.47, 95%CI: -0.62 to -0.32, I = 0, P = 0.687) were risk factors for sarcopenia in patients with stroke. The current analysis indicated sarcopenia was common in patients with stroke. Age, low albumin, low hemoglobin, stroke duration, length of hospital stay, and pneumonia history were the risk factors for sarcopenia in patients with stroke. This review will provide evidence for the screening and early identification of high-risk groups and the prevention of sarcopenia to improve the quality of life of stroke patients.
中风是全球第二大致死原因和第三大致残原因。骨骼肌在中风后的残疾中起关键作用。尽管许多研究报告了中风患者肌肉减少症的患病率和危险因素，但结果尚未进行综合分析。本系统评价旨在探讨中风患者肌肉减少症的患病率和危险因素。全面检索了PubMed、Embase、Cochrane图书馆、Web of Science、中国生物医学文献数据库（CBM）、中国知网（CNKI）、维普数据库（VIP）、万方数据库，以查找从创刊至2022年10月5日探索中风患者肌肉减少症患病率和危险因素的研究。本评价纳入了19项研究，涉及4148名受试者。中风患者肌肉减少症的总患病率为46%（95%置信区间，CI：40%至52%，I=94%，P<0.001）。年龄（MD=0.43，95%CI：0.06至0.81，I=88.3%，P<0.001）、中风病程（MD=0.20，95%CI：0.05至0.34，I=37.2%，P=0.189）、住院时间（MD=0.40，95%CI：0.20至0.59，I=0，P=0.393）、肺炎病史（OR=3.21，95%CI：1.98至5.20，I=0，P=0.343）、女性（OR=1.36，95%CI：1.09至1.70，I=48.7%，P=0.069）、白蛋白（MD=-0.43，95%CI：-0.58至-0.28，I=13.7%，P<0.001）、血红蛋白（MD=-0.47，95%CI：-0.62至-0.32，I=0，P=0.687）是中风患者肌肉减少症的危险因素。当前分析表明，肌肉减少症在中风患者中很常见。年龄、低白蛋白、低血红蛋白、中风病程、住院时间和肺炎病史是中风患者肌肉减少症的危险因素。本评价将为筛查和早期识别高危人群以及预防肌肉减少症提供证据，以提高中风患者的生活质量。
