Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan.
Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Eur J Clin Nutr. 2023 Jan;77(1):65-70. doi: 10.1038/s41430-022-01188-1. Epub 2022 Aug 11.
To examine whether bean intake (including soybeans) among Japanese adults is associated with risk of disabling dementia severe enough to require care under the national insurance system.
This cohort study involved 3739 individuals aged 40 to 64 years. The participants were categorized into five groups based on their dietary bean intake estimated by a 24h dietary recall. Hazard ratios and 95% confidence intervals of disabling dementia were estimated using Cox proportional hazard models adjusted for potential confounding factors (smoking, drinking, and intakes of energy and fish).
During the 59,681 person-year follow-up, 670 cases of disabling dementia were observed. A weak inverse association between bean intake and risk of disabling dementia was found; the multivariable hazard ratios (95% CIs) were 0.79 (0.62-1.00), 0.80 (0.63-1.01), 0.84 (0.67-1.06), and 0.78 (0.62-0.99) for the four groups with higher bean intake, respectively, compared with the lowest group (P for trend = 0.21). A significant inverse association was observed for dementia without a history of stroke; for the four groups with higher bean intake the multivariable hazard ratios were 0.81 (0.61-1.08), 0.70 (0.52-0.95), 0.71 (0.52-0.95), and 0.69 (0.51-0.92), respectively, (P for trend = 0.03). No such association was observed for dementia with history of stroke. The group with increased natto intake were inversely associated with risk of disabling dementia (P for trend = 0.003), but tofu intake was not (P for trend = 0.19).
Bean intake was inversely associated with risk of disabling dementia in those without a history of stroke.
研究日本成年人摄入豆类（包括大豆）是否与需要国家保险系统护理的致残性痴呆风险相关。
本队列研究纳入了 3739 名年龄在 40 至 64 岁的个体。根据 24 小时膳食回忆估计的膳食豆类摄入量，将参与者分为五组。使用 Cox 比例风险模型估计残疾性痴呆的风险比（HR）和 95%置信区间（CI），并调整了潜在混杂因素（吸烟、饮酒、能量和鱼类摄入）。
在 59681 人年的随访期间，观察到 670 例残疾性痴呆病例。发现豆类摄入量与致残性痴呆风险呈弱负相关；多变量 HR（95%CI）分别为 0.79（0.62-1.00）、0.80（0.63-1.01）、0.84（0.67-1.06）和 0.78（0.62-0.99），与最低组相比，摄入量较高的四个组（趋势 P 值=0.21）。对于无卒中史的痴呆，观察到显著的负相关；对于豆类摄入量较高的四个组，多变量 HR 分别为 0.81（0.61-1.08）、0.70（0.52-0.95）、0.71（0.52-0.95）和 0.69（0.51-0.92），趋势 P 值=0.03。对于有卒中史的痴呆，未观察到这种相关性。增加纳豆摄入量的组与致残性痴呆的风险呈负相关（趋势 P 值=0.003），但豆腐摄入量则没有（趋势 P 值=0.19）。
在无卒中史的个体中，豆类摄入与致残性痴呆风险呈负相关。
