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Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models.

作者信息

Jaeschke Hartmut, Ramachandran Anup

机构信息

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States.

出版信息

Toxicol Sci. 2025 Apr 1;204(2):251-252. doi: 10.1093/toxsci/kfae163.

DOI:10.1093/toxsci/kfae163
PMID:39729395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11939074/
Abstract
摘要

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本文引用的文献

1
Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models.对乙酰氨基酚作为评估体外肝模型的参考肝毒素的局限性。
Toxicol Sci. 2025 Jan 1;203(1):35-40. doi: 10.1093/toxsci/kfae133.
2
Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury.对乙酰氨基酚肝毒性：理解药物性肝损伤机制的范例。
Annu Rev Pathol. 2024 Jan 24;19:453-478. doi: 10.1146/annurev-pathmechdis-051122-094016.
3
The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers.4-甲基吡唑对乙酰氨基酚在人体志愿者氧化代谢的影响。
J Med Toxicol. 2020 Apr;16(2):169-176. doi: 10.1007/s13181-019-00740-z. Epub 2019 Nov 25.
4
4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.4-甲基吡唑可保护小鼠和原代人肝细胞免受对乙酰氨基酚的肝毒性作用。
Hum Exp Toxicol. 2018 Dec;37(12):1310-1322. doi: 10.1177/0960327118774902. Epub 2018 May 9.
5
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.对乙酰氨基酚诱导原代人肝细胞死亡的机制
Toxicol Appl Pharmacol. 2014 Sep 15;279(3):266-274. doi: 10.1016/j.taap.2014.05.010. Epub 2014 Jun 3.
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A gargantuan acetaminophen level in an acidemic patient treated solely with intravenous N-acetylcysteine.一位仅接受静脉注射乙酰半胱氨酸治疗的酸中毒患者体内出现巨大剂量的对乙酰氨基酚。
Am J Ther. 2013 Jan;20(1):104-6. doi: 10.1097/MJT.0b013e3181ff7ac0.
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Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.对乙酰氨基酚诱导的培养小鼠肝细胞氧化应激和细胞损伤：N-乙酰半胱氨酸的保护作用。
Toxicol Sci. 2004 Aug;80(2):343-9. doi: 10.1093/toxsci/kfh151. Epub 2004 Apr 28.
8
Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol.
J Pharmacol Exp Ther. 1990 Dec;255(3):935-41.