Zadik Z, Chalew S A, McCarter R J, Meistas M, Kowarski A A
J Clin Endocrinol Metab. 1985 Mar;60(3):513-6. doi: 10.1210/jcem-60-3-513.
We examined changes in spontaneously secreted growth hormone with aging by studying the 24-h integrated concentration of GH (IC-GH) of 173 nonobese subjects (height, greater than or equal to 5%; 7-65 yr of age). There was no significant difference in IC-GH on repeat testing of 13 men or in 23 women studied in the follicular and again in the luteal phase of the menstrual cycle. The level of IC-GH was strongly effected by age; children had the highest mean IC-GH, and there was a decline in IC-GH with increasing age after the second decade of life. The correlation of IC-GH with age was highly significant (r = 0.73; P less than 0.0001). There was no difference in IC-GH between males and females when matched for age. The mean IC-GH at Tanner stage 5 of puberty (7.4 +/- 2.0 ng/ml) was higher than that at stages 2-4 (5.7 +/- 1.4; P less than 0.0005) or that in prepubertal children (5.8 +/- 1.4; P less than 0.001). Thus, age and pubertal status must be carefully considered when interpreting the IC-GH for patients suspected of having deficient or excessive secretion of GH.
我们通过研究173名非肥胖受试者（身高大于或等于第5百分位数；年龄7 - 65岁）的24小时生长激素整合浓度（IC - GH），来探讨随着年龄增长自发分泌的生长激素的变化情况。在对13名男性进行重复检测时，以及对23名女性在月经周期的卵泡期和黄体期分别进行研究时，IC - GH均无显著差异。IC - GH水平受年龄的影响很大；儿童的平均IC - GH最高，在生命的第二个十年之后，IC - GH随着年龄的增长而下降。IC - GH与年龄的相关性非常显著（r = 0.73；P < 0.0001）。在年龄匹配时，男性和女性的IC - GH没有差异。青春期坦纳5期的平均IC - GH（7.4±2.0 ng/ml）高于2 - 4期（5.7±1.4；P < 0.0005）或青春期前儿童（5.8±1.4；P < 0.001）。因此，在解释疑似生长激素分泌不足或过多患者的IC - GH时，必须仔细考虑年龄和青春期状态。
