Talugula Snehitha, Nyenhuis Sharmilee M, Eldeirawi Kamal, Lee Victoria S
University of Illinois College of Medicine, 1853 W Polk St Chicago, IL 60612, USA.
University of Chicago, Department of Pediatrics, Section of Allergy and Immunology, 5841 S. Maryland Avenue Chicago, IL 60637, USA.
Am J Otolaryngol. 2025 Jan-Feb;46(1):104580. doi: 10.1016/j.amjoto.2024.104580. Epub 2024 Dec 19.
Environmental exposures may be associated with increased severity of chronic rhinosinusitis (CRS). However, research examining associations of traffic related air pollution with CRS is limited. The purpose of this study was to determine the association between residential traffic proximity and CRS with nasal polyposis (CRSwNP) severity in an existing database of adults in the United States.
This study was conducted on data gathered from 181 participants documented in the NAVIGATE I and NAVIGATE II randomized control trials within the OPTINOSE database. Zip codes for the testing locations of each participant were recorded and EPA traffic proximity data was extracted for each location. Traffic proximity was defined as the average annual daily traffic at major roads within the zip code. SNOT-22 scores were assessed as a measure of CRSwNP severity. The association between traffic proximity and SNOT-22 scores were determined using multiple linear regression.
There were 81 female and 100 male participants. The majority of participants were White not Hispanic (84.5 %). On adjusted regression, there was a weak but significant direct association of increased traffic proximity with SNOT-22 scores (β: 0.003; 95 % CI: 0.0003, 0.006; p = 0.03).
Increasing traffic proximity, suggestive of exposure to higher levels of pollution, was significantly associated with increased severity of CRSwNP. These findings suggest that pollutant exposure should be considered in CRS assessment and management. Future prospective studies on the association of traffic related air pollution and how pollutants affect symptom severity, may help to better elucidate the role the environment has in CRS.
环境暴露可能与慢性鼻窦炎（CRS）病情加重有关。然而，关于交通相关空气污染与CRS之间关联的研究有限。本研究旨在利用美国现有成人数据库，确定居住地区与交通的接近程度和伴鼻息肉的慢性鼻窦炎（CRSwNP）严重程度之间的关联。
本研究的数据来自OPTINOSE数据库中记录的181名参与者，这些参与者参与了NAVIGATE I和NAVIGATE II随机对照试验。记录每个参与者测试地点的邮政编码，并提取每个地点的美国环境保护局（EPA）交通接近程度数据。交通接近程度定义为邮政编码区域内主要道路的年平均日交通量。采用鼻窦鼻息肉症状测试-22（SNOT-22）评分评估CRSwNP的严重程度。使用多元线性回归确定交通接近程度与SNOT-22评分之间的关联。
有81名女性和100名男性参与者。大多数参与者为非西班牙裔白人（84.5%）。经调整回归分析，交通接近程度增加与SNOT-22评分之间存在微弱但显著的直接关联（β：0.003；95%置信区间：0.0003，0.006；p = 0.03）。
交通接近程度增加表明接触更高水平的污染，这与CRSwNP严重程度增加显著相关。这些发现表明，在CRS评估和管理中应考虑污染物暴露因素。未来关于交通相关空气污染的关联以及污染物如何影响症状严重程度的前瞻性研究，可能有助于更好地阐明环境在CRS中的作用。
