纤连蛋白对新生儿中性粒细胞黏附的影响。
Effect of fibronectin on adherence of neutrophils from newborn infants.
作者信息
Harris M C, Levitt J, Douglas S D, Gerdes J S, Polin R A
出版信息
J Clin Microbiol. 1985 Feb;21(2):243-6. doi: 10.1128/jcm.21.2.243-246.1985.
Abstract
Neutrophils (polymorphonuclear leukocytes [PMNs]) from infants and adults increased in adherence over a 20-min incubation as measured in a morphological assay. At each time point, PMNs from healthy infants had significantly diminished adherence when compared with those of adults; PMNs from sick newborn infants showed intermediate adherence values. Moreover, PMNs from healthy infants had significantly diminished membrane fluorescence for fibronectin when compared with those of adults. Preincubation with exogenous fibronectin did not augment the adherence of PMNs from infants or adults. Deficient adherence of PMNs from newborns may be related to decreased membrane fibronectin.
摘要
在一项形态学测定中，婴儿和成人的中性粒细胞（多形核白细胞[PMN]）在20分钟孵育期内黏附性增加。在每个时间点，与成人的中性粒细胞相比，健康婴儿的中性粒细胞黏附性显著降低；患病新生儿的中性粒细胞黏附性处于中间值。此外，与成人的中性粒细胞相比，健康婴儿的中性粒细胞纤连蛋白膜荧光显著降低。用外源性纤连蛋白预孵育并未增强婴儿或成人中性粒细胞的黏附性。新生儿中性粒细胞黏附性不足可能与膜纤连蛋白减少有关。
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本文引用的文献
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Fibronectin and collagen inhibit cell-substratum adhesion of neutrophil granulocytes.纤连蛋白和胶原蛋白可抑制中性粒细胞与基质的黏附。
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Neutrophils synthesize and deposit fibronectin on surfaces to which they attach.中性粒细胞在其附着的表面合成并沉积纤连蛋白。
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