Li Qi, Xu Yu-Xiang, Lu Xiu-Zhen, Shen Yu-Ting, Wan Yu-Hui, Su Pu-Yu, Tao Fang-Biao, Chen Xin, Sun Ying
Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
Key Laboratory of Oral Diseases Research of Anhui Province, Stomatologic Hospital & College, Anhui Medical University, Hefei, Anhui, China.
Ecotoxicol Environ Saf. 2025 Jan 15;290:117589. doi: 10.1016/j.ecoenv.2024.117589. Epub 2024 Dec 26.
Light at night (LAN) has become a global concern. However, little is known about the effects of bedroom LAN exposure on glucose metabolism markers. We aimed to explore the association between intensity and duration of bedroom LAN exposure with glucose metabolism markers, and the role of circadian-dependent meal timing in these associations.
Real-ambient bedroom LAN exposure was measured using a portable illuminance meter for two consecutive days. Seven consecutive days of sleep time and 24-h dietary records were assessed by wrist-worn accelerometer and mobile phone photos, respectively. Circadian-dependent meal timing, including the timing of meal relative to clock time and sleep time, was calculated from 24-h dietary records and sleep data.
The mean age of participants was 18.7 years, and 32.8 % were male. Per SD lx increase of bedroom LAN was associated with 1.75 μU/mL-increase in INS (95 %CI: 0.10, 2.50), 0.61 unit-increase in HOMA-IR (95 %CI: 0.43, 0.79), and 0.09 unit-increase in TyG (95 %CI: 0.04, 0.15); per SD min increase of bedroom LAN3 was associated with 1.61 μU/mL-increase in INS (95 %CI: 0.84, 2.37), 0.48 unit-increase in HOMA-IR (95 %CI: 0.29, 0.67), and 0.07 unit-increase in TyG (95 %CI: 0.01, 0.13). Nevertheless, these associations were found to be significant in later circadian-dependent meal timing group while weaker or not significant in earlier circadian-dependent meal timing group (time of first meal ≤ 9:00, time of last meal ≤ 19:00, first meal - sleep end ≤ 2 h, and sleep onset - last meal ≥ 5 h).
Overall, bedroom LAN exposure was associated with impaired glucose metabolism markers among young adults. Importantly, circadian-dependent meal timing may have potentially moderate effects on these associations. Keeping bedroom darkness at night and adhering to early eating pattern may be important public health strategies to reduce the risk of glucose metabolism disorders.
夜间光照（LAN）已成为全球关注的问题。然而，关于卧室LAN暴露对葡萄糖代谢标志物的影响知之甚少。我们旨在探讨卧室LAN暴露的强度和持续时间与葡萄糖代谢标志物之间的关联，以及昼夜节律依赖的进餐时间在这些关联中的作用。
使用便携式照度计连续两天测量卧室实际环境中的LAN暴露。分别通过腕部佩戴的加速度计和手机照片评估连续七天的睡眠时间和24小时饮食记录。根据24小时饮食记录和睡眠数据计算昼夜节律依赖的进餐时间，包括进餐时间相对于时钟时间和睡眠时间的情况。
参与者的平均年龄为18.7岁，男性占32.8%。卧室LAN每增加1个标准差lx，胰岛素（INS）增加1.75μU/mL（95%置信区间：0.10，2.50），胰岛素抵抗指数（HOMA-IR）增加0.61单位（95%置信区间：0.43，0.79），甘油三酯葡萄糖指数（TyG）增加0.09单位（95%置信区间：0.04，0.15）；卧室LAN3每增加1个标准差分钟，INS增加1.61μU/mL（95%置信区间：0.84，2.37），HOMA-IR增加0.48单位（95%置信区间：0.29，0.67），TyG增加0.07单位（95%置信区间：0.01，0.13）。然而，这些关联在昼夜节律依赖的进餐时间较晚的组中显著，而在昼夜节律依赖的进餐时间较早的组中较弱或不显著（第一餐时间≤9:00，最后一餐时间≤19:00，第一餐 - 睡眠结束时间≤2小时，睡眠开始 - 最后一餐时间≥5小时）。
总体而言，卧室LAN暴露与年轻人葡萄糖代谢标志物受损有关。重要的是，昼夜节律依赖的进餐时间可能对这些关联有潜在的调节作用。夜间保持卧室黑暗并坚持早期饮食模式可能是降低葡萄糖代谢紊乱风险的重要公共卫生策略。
