Xu Yu-Xiang, Yu Yang, Huang Yan, Wan Yu-Hui, Su Pu-Yu, Tao Fang-Biao, Sun Ying
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Environ Pollut. 2022 Feb 1;294:118628. doi: 10.1016/j.envpol.2021.118628. Epub 2021 Dec 6.
Indoor light environment has altered dramatically and exposure to light at night (LAN) potential leads to the progression of cardiometabolic conditions. However, few studies have investigated the effect of bedroom LAN exposure on cardiometabolic risk. To estimate the associations between multi-period bedroom LAN exposure with cardiometabolic risk among Chinese young adults. We objectively measured multi-period bedroom LAN intensity using portable illuminance meter in an ongoing prospective cohort (n = 484). At one-year follow-up, 230 young adults provided fasting blood samples for quantification of cardiometabolic parameters. Cardiometabolic (CM)-risk score was derived as the sum of standardized sex-specific z-scores for waist circumference (WC), mean arterial pressure (MAP), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and homeostasis model assessment for insulin resistance (HOMA-IR), with HDL-C multiplied by - 1. Multivariate and univariable linear regression models were used to examine associations of multi-period bedroom LAN exposure with cardiometabolic risk. Exposure to higher bedroom LAN intensity is associated with 1.47-unit increase in CM-risk score (95% CI: 0.69-2.25; P < 0.001). Besides, post-bedtime light exposure was associated with elevated fasting insulin (PBL-1h: β = 0.06, 95% CI: 0.01-0.10; PBL-4h: β = 0.33, 95% CI: 0.19-0.47) and HOMA-IR (PBL-1h: β = 0.013, 95% CI: 0-0.03; PBL-4h: β = 0.07, 95% CI: 0.04-0.11) while pre-awake light exposure was associated with elevated total cholesterol (PAL-1h: β = 0.03, 95% CI: 0.02-0.04; PAL-2h: β = 0.02, 95% CI: 0.01-0.03), triglyceride (PAL-1h: β = 0.015, 95% CI: 0.01-0.02; PAL-2h: β = 0.01, 95% CI: 0-0.02) and low-density lipoprotein cholesterol (PAL-1h: β = 0.02, 95% CI: 0.01-0.03; PAL-2h: β = 0.02, 95% CI: 0.01-0.03). Among young adults, bedroom LAN exposure was significantly associated with higher cardiometabolic risk. Furthermore, different periods of bedroom light exposure have time-dependent effect on cardiometabolic risk. Further research is needed to confirm our findings and to elucidate potential mechanisms.
室内光环境已发生显著变化，夜间光照暴露（LAN）可能导致心脏代谢疾病的进展。然而，很少有研究调查卧室LAN暴露对心脏代谢风险的影响。为了评估中国年轻成年人多时段卧室LAN暴露与心脏代谢风险之间的关联。我们在一个正在进行的前瞻性队列（n = 484）中使用便携式照度计客观测量了多时段卧室LAN强度。在一年的随访中，230名年轻成年人提供了空腹血样以量化心脏代谢参数。心脏代谢（CM）风险评分是通过将腰围（WC）、平均动脉压（MAP）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）和胰岛素抵抗稳态模型评估（HOMA-IR）的标准化性别特异性z评分相加得出的，其中HDL-C乘以 -1。使用多变量和单变量线性回归模型来检验多时段卧室LAN暴露与心脏代谢风险之间的关联。卧室LAN强度较高的暴露与CM风险评分增加1.47单位相关（95%置信区间：0.69 - 2.25；P < 0.001）。此外，就寝后光照暴露与空腹胰岛素升高相关（PBL - 1小时：β = 0.06，95%置信区间：0.01 - 0.10；PBL - 4小时：β = 0.33，95%置信区间：0.19 - 0.47）和HOMA - IR相关（PBL - 1小时：β = 0.013，95%置信区间：0 - 0.03；PBL - 4小时：β = 0.07，95%置信区间：0.04 - 0.11），而醒来前光照暴露与总胆固醇升高相关（PAL - 1小时：β = 0.03，95%置信区间：0.02 - 0.04；PAL - 2小时：β = 0.02，95%置信区间：0.01 - 0.03）、甘油三酯升高相关（PAL - 1小时：β = 0.015，95%置信区间：0.01 - 0.02；PAL - 2小时：β = 0.01，95%置信区间：0 - 0.02）和低密度脂蛋白胆固醇升高相关（PAL - 1小时：β = 0.02，95%置信区间：0.01 - 0.03；PAL - 2小时：β = 0.02，95%置信区间：0.01 - 0.03）。在年轻成年人中，卧室LAN暴露与较高的心脏代谢风险显著相关。此外，卧室不同时段的光照暴露对心脏代谢风险有时间依赖性影响。需要进一步的研究来证实我们的发现并阐明潜在机制。
