Liu Xiliang, Qian Zhendong, Li Yuxuan, Wang Yanwei, Zhang Yan, Zhang Yu, Enoch Israel V M V
Department of Rehabilitation Medicine, Dezhou Traditional Chinese Medicine Hospital, Dezhou 253000, China.
Department of Rehabilitation Medicine, Dezhou Traditional Chinese Medicine Hospital, Dezhou 253000, China.
Neuroscience. 2025 Feb 16;567:109-122. doi: 10.1016/j.neuroscience.2024.12.043. Epub 2024 Dec 25.
This review explores the mechanisms and treatment strategies of ischemic stroke, a leading cause of morbidity and mortality worldwide. Ischemic stroke results from the obstruction of blood flow to the brain, leading to significant neurological impairment. The paper categorizes ischemic stroke into subtypes based on etiology, including cardioembolism and large artery atherosclerosis, and discusses the challenges of current therapeutic approaches. Conventional treatments like tissue plasminogen activator (tPA) and surgical interventions are limited by narrow windows and potential complications. The review highlights the promise of acupuncture, which offers neuroprotective benefits by promoting cerebral ischemic tolerance and neural regeneration. Integrating acupuncture with conventional treatments may enhance patient outcomes. Emphasis is placed on understanding the pathophysiology to develop targeted therapies that mitigate neuronal damage and enhance recovery.
本综述探讨了缺血性中风的发病机制和治疗策略，缺血性中风是全球发病和死亡的主要原因。缺血性中风是由于大脑血流受阻导致严重的神经功能障碍。本文根据病因将缺血性中风分为不同亚型，包括心源性栓塞和大动脉粥样硬化，并讨论了当前治疗方法面临的挑战。像组织型纤溶酶原激活剂（tPA）和手术干预等传统治疗方法受到狭窄治疗窗和潜在并发症的限制。该综述强调了针灸的前景，针灸通过促进脑缺血耐受性和神经再生提供神经保护益处。将针灸与传统治疗相结合可能会改善患者的治疗效果。重点在于理解病理生理学以开发减轻神经元损伤和促进恢复的靶向治疗方法。
