Lu Zhiyi, Zhang Qi, Mei Xinyi
Medical College, Wuhan University of Science and Technology, Wuhan, China.
China Resources Wuhan Steel General Hospital, Qingshan District, Wuhan, Hubei, China.
Sci Rep. 2024 Dec 28;14(1):31091. doi: 10.1038/s41598-024-82225-w.
Aspirin may be necessary for some patients with cardiovascular disease, but previous studies on the use and dosage of aspirin and the association with hypertension have been inadequate. The results of existing studies have been somewhat inconsistent. Our study was designed to assess the association between prophylactic aspirin use and hypertension in U.S. adults. This cross-sectional study analyzed a nationally representative sample of U.S. adults aged 40 and older from the National Health and Nutrition Examination Survey (2011-2018). Aspirin was categorized as no use, low dose (≤ 100 mg), and high dose (> 100 mg). Hypertension was defined as the average of three consecutive blood pressure readings (systolic ≥ 140 mmHg or diastolic ≥ 90 mmHg). There were 5297 participants, comprising 52.5% male and 47.4% female. The median age was 64 years (range: 56 to 72) and 3635 individuals were diagnosed with high blood pressure. Among the groups, the incidence of hypertension was 70.2% in the non-aspirin group, 68.3% in the low-dose group, and 68.0% in the high-dose group, with no statistically significant difference observed (p = 0.71). Using a fully adjusted weighted multivariate logistic regression model 4, prophylactic aspirin use was not associated with hypertension [(odds ratio [OR] 1.11; 95% CI (0.89-1.38), (odds ratio [OR] 1.15; 95% CI 0.82-1.61), P = 0.31]. Subgroup analyses, along with sensitivity analyses that excluded patients with diabetes and reclassified aspirin use status, confirmed the findings of the main study. In this nationally representative cohort of U.S. adults, no significant association was found between aspirin use or dosage and the prevalence of hypertension.
对于一些心血管疾病患者来说，阿司匹林可能是必要的，但先前关于阿司匹林的使用、剂量以及与高血压之间关联的研究并不充分。现有研究结果在一定程度上并不一致。我们的研究旨在评估美国成年人预防性使用阿司匹林与高血压之间的关联。这项横断面研究分析了来自美国国家健康与营养检查调查（2011 - 2018年）的40岁及以上美国成年人的全国代表性样本。阿司匹林被分为未使用、低剂量（≤100毫克）和高剂量（>100毫克）。高血压定义为连续三次血压读数的平均值（收缩压≥140毫米汞柱或舒张压≥90毫米汞柱）。共有5297名参与者，其中男性占52.5%，女性占47.4%。中位年龄为64岁（范围：56至72岁），3635人被诊断患有高血压。在各分组中，未使用阿司匹林组的高血压发病率为70.2%，低剂量组为68.3%，高剂量组为68.0%，未观察到统计学上的显著差异（p = 0.71）。使用完全调整的加权多变量逻辑回归模型4，预防性使用阿司匹林与高血压无关[比值比（OR）1.11；95%置信区间（0.89 - 1.38），（比值比（OR）1.15；95%置信区间0.82 - 1.61），P = 0.31]。亚组分析以及排除糖尿病患者并重新分类阿司匹林使用状态的敏感性分析证实了主要研究的结果。在这个具有全国代表性的美国成年人队列中，未发现阿司匹林的使用或剂量与高血压患病率之间存在显著关联。
