时空转录组学揭示凝溶胶蛋白是心肌梗死后心室重塑的关键调节因子。 - Suppr

Spatiotemporal transcriptomics unveil gelsolin as a critical regulator in ventricular remodeling after myocardial infarction.

作者信息

Wang Wenting, Liu Yanfei, Liu Longkun, Xu Qian, Li Yiwen, Zhu Mengmeng, Cui Jing, Chen Keji, Liu Yue

机构信息

National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

The Second Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

出版信息

Sci China Life Sci. 2025 Jun;68(6):1835-1838. doi: 10.1007/s11427-024-2806-2. Epub 2024 Dec 24.

DOI:10.1007/s11427-024-2806-2

PMID:39730850

Abstract

摘要

相似文献

Spatiotemporal transcriptomics unveil gelsolin as a critical regulator in ventricular remodeling after myocardial infarction.时空转录组学揭示凝溶胶蛋白是心肌梗死后心室重塑的关键调节因子。

Sci China Life Sci. 2025 Jun;68(6):1835-1838. doi: 10.1007/s11427-024-2806-2. Epub 2024 Dec 24.

Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis.凝溶胶蛋白通过脱氧核糖核酸酶I介导的细胞凋亡调节心肌梗死后的心脏重塑。

Circ Res. 2009 Apr 10;104(7):896-904. doi: 10.1161/CIRCRESAHA.108.172882. Epub 2009 Feb 26.

Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction.时空转录组分析揭示了机械传感基因在心肌梗死后重塑边缘区的关键作用。

Nat Cardiovasc Res. 2022 Nov;1(11):1072-1083. doi: 10.1038/s44161-022-00140-7. Epub 2022 Nov 17.

Blood PGC-1α Concentration Predicts Myocardial Salvage and Ventricular Remodeling After ST-segment Elevation Acute Myocardial Infarction.血液中PGC-1α浓度可预测ST段抬高型急性心肌梗死后的心肌挽救和心室重构。

Rev Esp Cardiol (Engl Ed). 2015 May;68(5):408-16. doi: 10.1016/j.rec.2014.05.020. Epub 2014 Nov 5.

Gelsolin and cardiac myocyte apoptosis: a new target in the treatment of postinfarction remodeling.凝溶胶蛋白与心肌细胞凋亡：心肌梗死后重塑治疗的新靶点

Circ Res. 2009 Apr 10;104(7):829-31. doi: 10.1161/CIRCRESAHA.109.196329.

Brain natriuretic peptide and other cardiac markers predicting left ventricular remodeling and function two years after myocardial infarction.脑钠肽及其他心脏标志物对心肌梗死后两年左心室重构和功能的预测作用

Medicina (Kaunas). 2007;43(9):708-15.

Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy.急性ST段抬高型心肌梗死后有不良重塑风险的患者，冠状动脉内注射骨髓源性祖细胞可改善左心室功能：急性心肌梗死中富集祖细胞再输注与梗死重塑研究（REPAIR-AMI）心脏磁共振成像子研究结果

Am Heart J. 2009 Mar;157(3):541-7. doi: 10.1016/j.ahj.2008.11.011. Epub 2009 Jan 31.

[Myocardial performance index: prediction and monitoring of remodeling and functioning of the left ventricle after first myocardial infarction].[心肌性能指数：首次心肌梗死后左心室重构和功能的预测与监测]

Med Pregl. 2010 Sep-Oct;63(9-10):652-5. doi: 10.2298/mpns1010652c.

Using ultrasound three-dimensional speckle tracking technology to explore the role of SIRT1 in ventricular remodeling after myocardial infarction.运用超声三维斑点追踪技术探索 SIRT1 在心肌梗死后心室重构中的作用。

Eur Rev Med Pharmacol Sci. 2020 Oct;24(20):10632-10645. doi: 10.26355/eurrev_202010_23421.

Effects of Compound Danshen Dripping Pills on Ventricular Remodeling and Cardiac Function after Acute Anterior Wall ST-Segment Elevation Myocardial Infarction (CODE-AAMI): Protocol for a Randomized Placebo-Controlled Trial.复方丹参滴丸对急性前壁 ST 段抬高型心肌梗死患者心室重构及心功能的影响（CODE-AAMI）：一项随机安慰剂对照试验的方案。

Chin J Integr Med. 2023 Dec;29(12):1059-1065. doi: 10.1007/s11655-023-3648-6. Epub 2023 Sep 1.

引用本文的文献

Application of Spatial Omics in the Cardiovascular System.空间组学在心血管系统中的应用。

Research (Wash D C). 2025 Mar 8;8:0628. doi: 10.34133/research.0628. eCollection 2025.

本文引用的文献

Crotonylation of NAE1 Modulates Cardiac Hypertrophy via Gelsolin Neddylation.NAE1 的琥珀酰化修饰通过凝溶胶蛋白的类泛素化调节心脏肥大。

Circ Res. 2024 Sep 27;135(8):806-821. doi: 10.1161/CIRCRESAHA.124.324733. Epub 2024 Sep 4.

A transient wave of Bhlhe41 resident macrophages enables remodeling of the developing infarcted myocardium.一过性 Bhlhe41 驻留巨噬细胞波可重塑发育中梗死的心肌。

Cell Rep. 2023 Oct 31;42(10):113174. doi: 10.1016/j.celrep.2023.113174. Epub 2023 Sep 25.

Platelet-instructed SPP1 macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner.血小板指导的 SPP1 巨噬细胞以 CXCL4 依赖的方式驱动纤维化中的肌成纤维细胞激活。

Cell Rep. 2023 Feb 28;42(2):112131. doi: 10.1016/j.celrep.2023.112131. Epub 2023 Feb 18.

Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction.实验性心肌梗死中单核细胞衍生的巨噬细胞多样性的动力学。

Cardiovasc Res. 2023 May 2;119(3):772-785. doi: 10.1093/cvr/cvac113.

Sudden cardiac death after myocardial infarction.心肌梗死后的心源性猝死。

Eur J Heart Fail. 2020 May;22(5):856-858. doi: 10.1002/ejhf.1744. Epub 2020 Jan 23.

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.PI3Kα 调节的凝胶蛋白活性是心脏细胞骨架重构和心脏病的关键决定因素。

Nat Commun. 2018 Dec 19;9(1):5390. doi: 10.1038/s41467-018-07812-8.

MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin.miR-21 通过靶向凝溶胶蛋白保护糖尿病心肌病诱导的舒张功能障碍。

Cardiovasc Diabetol. 2018 Sep 4;17(1):123. doi: 10.1186/s12933-018-0767-z.

Monocyte recruitment during infection and inflammation.感染和炎症期间的单核细胞募集。

Nat Rev Immunol. 2011 Oct 10;11(11):762-74. doi: 10.1038/nri3070.

Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease.血小板凝胶蛋白与冠心病血瘀证的相关性研究。

Chin J Integr Med. 2011 Aug;17(8):587-92. doi: 10.1007/s11655-011-0814-z. Epub 2011 Aug 9.

Circ Res. 2009 Apr 10;104(7):896-904. doi: 10.1161/CIRCRESAHA.108.172882. Epub 2009 Feb 26.

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Spatiotemporal transcriptomics unveil gelsolin as a critical regulator in ventricular remodeling after myocardial infarction.

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