Giolli R A, Blanks R H, Torigoe Y, Williams D D
J Comp Neurol. 1985 Feb 1;232(1):99-116. doi: 10.1002/cne.902320109.
Projections of the medial terminal nucleus (MTN) of the accessory optic system, the ventral tegmental area of Tsai, and the substantia nigra of the rabbit and the rat have been studied by the method of retrograde axonal transport of horseradish peroxidase. The data show that MTN projections are remarkably similar in the rabbit and rat. The MTN projects heavily to the ipsilateral nucleus of the optic tract and dorsal terminal nucleus of the accessory optic system and to a portion of the contralateral ventral tegmental area of Tsai that we have termed the visual tegmental relay zone (VTRZ). Further, the MTN sends projections to the ipsilateral mesencephalic (deep mesencephalic nucleus, pars medialis) and pontine (nucleus reticularis pontis oralis) reticular formations; the contralateral dorsolateral division of the basal pontine complex; the superior and lateral vestibular nuclei (contralateral in rat; bilateral in rabbit); and the ipsi- and contralateral interstitial nucleus of Cajal, nucleus of Darkschewitsch, and supraoculomotor-periaqueductal gray. The findings also indicate that the MTN has a small bilateral, but mainly ipsilateral, projection to the dorsal cap, its ventrolateral outgrowth, and the B division of the inferior olivary complex. This study further reveals that ventral tegmental nuclei (n. parabrachialis pigmentosus and n. paranigralis) and subdivisions of the substantia nigra (pars compacta and pars reticulata) project to many brain stem targets of the MTN. Thus, the VTRZ projections are similar to those of the MTN in both distribution and density except that the VTRZ projection to the inferior olive is substantially stronger. The nucleus parabrachialis pigmentosus sends a small contralateral projection to the VTRZ and a moderate-sized bilateral projection to the supraoculomotor-periaqueductal gray. The nucleus paranigralis sends a moderate number of axons to the ipsilateral deep mesencephalic nucleus, pars medialis, and the nucleus reticularis pontis oralis and provides a strong bilateral projection to the supraoculomotor-periaqueductal gray. The pars compacta of the substantia nigra provides a sparse input to the ipsilateral deep mesencephalic nucleus, pars medialis, and nucleus reticularis pontis oralis, and to the contralateral VTRZ and sends a moderate number of axons, bilaterally, to the supraoculomotor-periaqueductal gray. The pars reticulata of the substantia nigra sends an ipsiateral projection of moderate size to the intermediate and deep layers of the superior colliculus, sparse ipsilateral projections to the deep mesencephalic nucleus, pars medialis, and nucleus reticularis pontis oralis, and a sparse bilateral projection to
采用辣根过氧化物酶逆行轴突运输法，对家兔和大鼠副视系统的内侧终核（MTN）、蔡氏腹侧被盖区及黑质的投射进行了研究。数据表明，家兔和大鼠的MTN投射极为相似。MTN大量投射至同侧视束核及副视系统的背侧终核，以及对侧腹侧被盖区的一部分，我们将其称为视觉被盖中继区（VTRZ）。此外，MTN还向同侧中脑（中脑深核，内侧部）和脑桥（脑桥网状核嘴侧部）网状结构投射；向对侧脑桥基底复合体的背外侧部投射；向前庭上核和外侧核投射（大鼠为对侧，家兔为双侧）；向同侧和对侧的 Cajal 间质核、Darkschewitsch 核及动眼神经上核-导水管周围灰质投射。研究结果还表明，MTN对背帽及其腹外侧延伸部以及下橄榄复合体的 B 亚核有少量双侧但主要为同侧的投射。本研究进一步揭示，腹侧被盖核（臂旁色素核和旁黑质核）及黑质的亚区（致密部和网状部）投射至 MTN 的许多脑干靶区。因此，VTRZ 的投射在分布和密度上与 MTN 的相似，只是 VTRZ 向下橄榄的投射明显更强。臂旁色素核向 VTRZ 发出少量对侧投射，向动眼神经上核-导水管周围灰质发出中等大小的双侧投射。旁黑质核向同侧中脑深核内侧部和脑桥网状核嘴侧部发出中等数量的轴突，并向动眼神经上核-导水管周围灰质提供强大的双侧投射。黑质致密部向同侧中脑深核内侧部和脑桥网状核嘴侧部以及对侧 VTRZ 提供稀疏的输入，并向动眼神经上核-导水管周围灰质双侧发出中等数量的轴突。黑质网状部向同侧上丘的中间层和深层发出中等大小的投射，向同侧中脑深核内侧部和脑桥网状核嘴侧部发出稀疏的同侧投射，并向……发出稀疏的双侧投射
