Bian Liya, Tang Ting, Yu Qingwen, Tong Xuhan, Hu Siqi, You Yao, Zhang Shenghui, Wang Hu, Fu Xinyan, Chen Juan, Zhang Xingwei, Wang Mingwei, Zhang Pengwei
Department of Cardiology, Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Zhejiang Key Laboratory of Medical Epigenetics, Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Affiliated Hospital of Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Hangzhou Normal University, Hangzhou, 310015, China.
The First People's Hospital of Jiande, Hangzhou, 311600, China.
Sci Rep. 2024 Dec 28;14(1):31048. doi: 10.1038/s41598-024-82116-0.
This study evaluated the ability of the triglyceride (TG) to high-density lipoprotein cholesterol (TG/HDL-C) ratio to identify individuals at risk of type 2 diabetes mellitus (T2DM) in the non-alcoholic fatty liver disease (NAFLD) population. We retrospectively studied 4,769 patients with NAFLD from the Affiliated Hospital of Hangzhou Normal University (2020-2023). Binary logistic regression models were used to evaluate the association between the TG/HDL-C ratio and lipid parameters with T2DM. TG/HDL-C ratio was positively associated with T2DM in patients with NAFLD, with an odds ratio (OR) of 2.72 (95% confidence interval, 2.23-3.31, p < 0.001) for T2DM in the highest TG/HDL-C ratio quartile compared with the lowest one after adjusting for known confounders. The OR for the TG/HDL-C ratio had a stronger predictive value than those of TG, total cholesterol, HDL-C, and low-density lipoprotein cholesterol, indicating that the TG/HDL-C ratio could be a better discriminator of T2DM. The TG/HDL-C ratio better identifies potential risks of T2DM in individuals with NAFLD than individual lipid parameters. Therefore, clinicians should pay attention to individuals with high TG and low HDL-C levels during T2DM risk assessment in NAFLD cohorts.
本研究评估了甘油三酯（TG）与高密度脂蛋白胆固醇之比（TG/HDL-C）在非酒精性脂肪性肝病（NAFLD）人群中识别2型糖尿病（T2DM）风险个体的能力。我们回顾性研究了杭州师范大学附属医院2020年至2023年期间的4769例NAFLD患者。采用二元逻辑回归模型评估TG/HDL-C比值和血脂参数与T2DM之间的关联。在NAFLD患者中，TG/HDL-C比值与T2DM呈正相关，在调整已知混杂因素后，TG/HDL-C比值最高四分位数组的T2DM比值比（OR）为2.72（95%置信区间为2.23 - 3.31，p < 0.001），而最低四分位数组与之相比。TG/HDL-C比值的OR比TG、总胆固醇、HDL-C和低密度脂蛋白胆固醇具有更强的预测价值，表明TG/HDL-C比值可能是T2DM更好的判别指标。与单个血脂参数相比，TG/HDL-C比值能更好地识别NAFLD个体患T2DM的潜在风险。因此，临床医生在NAFLD队列的T2DM风险评估中应关注TG水平高和HDL-C水平低的个体。
