Casey M A, Feldman M L
J Comp Neurol. 1985 Feb 15;232(3):401-13. doi: 10.1002/cne.902320311.
The medial nucleus of the trapezoid body (MTB), the largest cell group of the rat superior olivary complex, was studied ultrastructurally in five groups of rats ranging in age from 2 to 33 months. Relatively little aging pigment (lipofuscin) accumulates intraneuronally, even in rats aged 33 months. The heaviest accumulation of age pigment is in glial and perivascular cells of the MTB. In rats aged 24-33 months, there is evidence of axonal and dendritic degeneration in the MTB neuropil. Aged rats also show evidence of degeneration of nerve endings. This includes the loss of calycine axosomatic terminals synapsing with MTB principal cells. All of the ultrastructural changes observed in the MTB gradually increase in frequency with advancing age.
研究了年龄在2至33个月的五组大鼠的斜方体内侧核（MTB），它是大鼠上橄榄复合体中最大的细胞群。即使在33个月大的大鼠中，神经元内积累的衰老色素（脂褐素）也相对较少。年龄色素在MTB的神经胶质细胞和血管周围细胞中积累最多。在24至33个月大的大鼠中，有证据表明MTB神经毡中存在轴突和树突退化。老年大鼠也有神经末梢退化的证据。这包括与MTB主细胞形成突触的杯状轴体终末的丧失。在MTB中观察到的所有超微结构变化的频率都随着年龄的增长而逐渐增加。
