Bongkotvirawan Phubordee, Aumpan Natsuda, Pornthisarn Bubpha, Chonprasertsuk Soonthorn, Siramolpiwat Sith, Bhanthumkomol Patommatat, Nunanun Pongjarat, Issariyakulkarn Navapan, Mahachai Varocha, Pawa Kammal Kumar, Vilaichone Ratha-Korn
Center of Excellence in Digestive Diseases and Gastroenterology Unit, Department of Medicine, Thammasat University, Pathumthani, Thailand.
Department of Medicine, Chulabhorn International College of Medicine (CICM) at Thammasat University, Pathumthani, Thailand.
Womens Health Rep (New Rochelle). 2024 Feb 23;5(1):178-185. doi: 10.1089/whr.2023.0069. eCollection 2024.
Association of Southeast Asian Nations (ASEAN) countries have high infections, and gastric cancer (GC) is a leading fatal cancer in this region, especially in female patients. This study aimed to compare clinical manifestations, histopathological subtypes, and prognostic factors associated with the overall survival rate of female GC patients in this important region.
This retrospective cohort study was conducted between 2007 and 2022 at a tertiary care center in Thailand. All clinical information, endoscopic findings, and histological types were extensively reviewed. Furthermore, all qualified studies in ASEAN published in PubMed and Scopus between 2000 and 2022 were extracted and thoroughly analyzed. Young female GC patients are defined as those ≤50 years of age.
A total of 98 Thai female GC patients were included, with a mean age of 58.99 ± 14 years; 70.4% were elderly women. The common presenting symptoms were weight loss (69.4%) and dyspepsia (68.4%). Younger female GC patients had significantly more common diffuse-type GC than elderly female GC patients (82.8% vs. 53.6%, -value = 0.007). Moreover, elderly female GC patients demonstrated significantly better survival than younger female GC patients (44.8% vs. 20.7%, odds ratio = 3.49; 95% confidence interval: 1.20-10.14, -value = 0.022). Furthermore, a total of 1,491 female GC patients from ASEAN were reviewed and included in this study, aged 15 to 93 years. The top three countries with the highest proportion of female GC from ASEAN were Indonesia (66.7%), Thailand (44.9%), and Singapore (38.4%).
GC in women is not uncommon in ASEAN and presents at an advanced stage with a grave prognosis. This study showed that ASEAN countries with the highest disease burden were Indonesia, Thailand, and Singapore. Overall, survival rates for female GC patients in ASEAN countries were relatively low, highlighting the need for proactive measures such as intensive eradication and the development of early detection methods for GC.
东南亚国家联盟（东盟）国家感染率较高，胃癌（GC）是该地区主要的致命癌症，尤其是在女性患者中。本研究旨在比较该重要地区女性GC患者的临床表现、组织病理学亚型以及与总生存率相关的预后因素。
本回顾性队列研究于2007年至2022年在泰国的一家三级医疗中心进行。对所有临床信息、内镜检查结果和组织学类型进行了广泛回顾。此外，提取并深入分析了2000年至2022年在PubMed和Scopus上发表的东盟地区所有合格研究。年轻女性GC患者定义为年龄≤50岁的患者。
共纳入98例泰国女性GC患者，平均年龄为58.99±14岁；70.4%为老年女性。常见的首发症状为体重减轻（69.4%）和消化不良（68.4%）。年轻女性GC患者中弥漫型GC比老年女性GC患者更为常见（82.8%对53.6%，P值=0.007）。此外，老年女性GC患者的生存率明显高于年轻女性GC患者（44.8%对20.7%，比值比=3.49；95%置信区间：1.20 - 10.14，P值=0.022）。此外，本研究共纳入并回顾了1491例来自东盟的女性GC患者，年龄在15至93岁之间。东盟地区女性GC比例最高的前三个国家是印度尼西亚（66.7%）、泰国（44.9%）和新加坡（38.4%）。
在东盟地区，女性GC并不罕见，且多在晚期出现，预后严重。本研究表明，疾病负担最高的东盟国家是印度尼西亚、泰国和新加坡。总体而言，东盟国家女性GC患者的生存率相对较低，这凸显了采取积极措施的必要性，如强化根除以及开发GC早期检测方法。
