Zhang Yufei, Gesang Pingcuo, Zhou Yaxi, Ding Kangzhi, Wan Yang, Xiong Hai
Medical College of Tibet University, No. 10 East Zangda Road,Chengguan District, Lhasa, 850000, China.
Tibet Autonomous Region Center for Disease Control and Prevention (CDC), Chengguan District, Tibet Autonomous Region, No. 21, Linkuo North Road, Lhasa, 850000, China.
BMC Public Health. 2024 Dec 27;24(1):3595. doi: 10.1186/s12889-024-21160-x.
The prevalence of hypertension among the Tibetan population in Tibet is higher than in other regions of China, and there is a lack of unified epidemiological surveys. This study aims to conduct a standardized epidemiological investigation to assess the current status of hypertension among the Tibetan population, as well as to explore the dose-response relationship between cholesterol (TC), triglyceride glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), and hypertension in this population.
From June 2020 to July 2023, a total of 5042 Tibetans aged 18 to 80 years from three cities and one region in Tibet were randomly sampled for the study. Logistic regression analysis models combined with restricted cubic splines were used to analyze the relationship between LDL-C, TC, TyG, TyG-BMI index, and HTN in the Tibetan population.
(1) The prevalence of HTN in the Tibetan population in Tibet, China, was 32.35%, of which men were slightly higher than women. (2) Age, BMI, fasting blood glucose (FBG), uric acid (UA), TC, triglycerides (TG), LDL-C, homocysteine (Hcy), TyG, and TyG-BMI were higher in HTN populations compared to non-HTN populations (P < 0.05). (3) The risk of HTN was increased in individuals with borderline elevated and elevated LDL-C, borderline elevated TC, the second(Q2), third(Q3), and fourth quartile groups(Q4) of TyG as well as the third(Q3) and fourth quartile groups(Q4) of TyG-BMI. The prevalence risk of HTN gradually increased with elevated levels of LDL-C, TC, TyG, and TyG-BMI (P trend < 0.001). (4) The results of restricted cubic spline analysis showed a nonlinear dose-response relationship between LDL-C, TC, and TyG-BMI and the risk of developing HTN (P < 0.001, P < 0.05), and a linear dose-response relationship between TyG and the risk of developing HTN (P < 0.001, P > 0.05).
Higher LDL-C, TC, TyG, and TyG-BMI are risk factors for HTN in the Tibetan population of Tibet, China. Effective prevention can be achieved by controlling lipid and glucose indices.
西藏藏族人群高血压患病率高于中国其他地区，且缺乏统一的流行病学调查。本研究旨在进行标准化的流行病学调查，以评估藏族人群高血压的现状，并探讨胆固醇（TC）、甘油三酯葡萄糖指数（TyG）、甘油三酯葡萄糖-体重指数（TyG-BMI）与该人群高血压之间的剂量反应关系。
2020年6月至2023年7月，从西藏三个市和一个地区随机抽取5042名年龄在18至80岁的藏族人进行研究。采用逻辑回归分析模型结合受限立方样条分析藏族人群中低密度脂蛋白胆固醇（LDL-C）、TC、TyG、TyG-BMI指数与高血压（HTN）之间的关系。
（1）中国西藏藏族人群中HTN患病率为32.35%，其中男性略高于女性。（2）与非HTN人群相比，HTN人群的年龄、体重指数（BMI）、空腹血糖（FBG）、尿酸（UA）、TC、甘油三酯（TG）、LDL-C、同型半胱氨酸（Hcy）、TyG和TyG-BMI更高（P<0.05）。（3）LDL-C边缘升高和升高、TC边缘升高、TyG的第二四分位数组（Q2）、第三四分位数组（Q3）和第四四分位数组（Q4）以及TyG-BMI的第三四分位数组（Q3）和第四四分位数组（Q4）的个体患HTN的风险增加。HTN的患病风险随着LDL-C、TC、TyG和TyG-BMI水平的升高而逐渐增加（P趋势<0.001）。（4）受限立方样条分析结果显示，LDL-C、TC和TyG-BMI与发生HTN的风险之间存在非线性剂量反应关系（P<0.001，P<0.05），TyG与发生HTN的风险之间存在线性剂量反应关系（P<0.001，P>0.05）。
较高的LDL-C、TC、TyG和TyG-BMI是中国西藏藏族人群HTN的危险因素。通过控制血脂和血糖指标可实现有效预防。
