Lee Dong-Hwa, Park Jong Eun, Kim So Young, Jeon Hyun Jeong, Park Jong-Hyock
Department of Internal Medicine, Chungbuk National University College of Medicine and Chungbuk National University Hospital, Cheongju, Republic of Korea.
Institute of Health & Science Convergence, Chungbuk National University, Cheongju, Republic of Korea.
Diabetol Metab Syndr. 2022 Oct 29;14(1):161. doi: 10.1186/s13098-022-00927-5.
Insulin resistance (IR) is an important contributor to the development of hypertension (HTN), and the triglyceride-glucose (TyG) index has been proposed as a simple, reliable marker of IR. This study investigated the association between the TyG index and blood pressure (BP) elevation in a large general population.
The study enrolled 15,721 adults with no history of cardiometabolic diseases from the 2016-2019 Korea National Health and Nutrition Examination Survey. Participants were classified into quartiles based on the TyG index and BP was categorized as normal BP, elevated BP, pre-HTN, and HTN. The associations of the TyG index with BP categories were assessed using multivariate multinomial logistic regression models with normal BP as the reference group.
The mean systolic/diastolic BP and prevalence of HTN increased with the TyG index (P for trend < 0.001). The continuous TyG index had a strong dose-response relationship with increased odds of elevated BP, pre-HTN, and HTN. Compared with the lowest TyG index quartile, the highest TyG index quartile was significantly associated with higher odds of having elevated BP (odds ratio [OR], 1.52; 95% confidence interval [CI], 1.24-1.87; P for trend < 0.001), pre-HTN (OR, 2.22; 95% CI, 1.95-2.53; P for trend < 0.001), and HTN (OR, 4.24; 95% CI, 3.49-5.16; P for trend < 0.001).
We found that a higher TyG index was positively associated with the risk of increased BP in normal healthy individuals. This study suggests that the TyG index might serve as a potential predictor of HTN. However, further studies with larger sample sizes and various target populations in longitudinal designs are needed.
胰岛素抵抗（IR）是高血压（HTN）发生发展的重要因素，甘油三酯-葡萄糖（TyG）指数已被提议作为一种简单、可靠的IR标志物。本研究在一大群普通人群中调查了TyG指数与血压（BP）升高之间的关联。
该研究纳入了2016 - 2019年韩国国民健康与营养检查调查中15721名无心脏代谢疾病史的成年人。参与者根据TyG指数分为四分位数，血压分为正常血压、血压升高、高血压前期和高血压。以正常血压作为参照组，使用多变量多项逻辑回归模型评估TyG指数与血压分类之间的关联。
收缩压/舒张压均值和高血压患病率随TyG指数升高而增加（趋势P<0.001）。连续的TyG指数与血压升高、高血压前期和高血压的几率增加存在强烈的剂量反应关系。与TyG指数最低的四分位数相比，TyG指数最高的四分位数与血压升高（优势比[OR]，1.52；95%置信区间[CI]，1.24 - 1.87；趋势P<0.001）、高血压前期（OR，2.22；95%CI，1.95 - 2.53；趋势P<0.001）和高血压（OR，4.24；95%CI，3.49 - 5.16；趋势P<0.001）的较高几率显著相关。
我们发现较高的TyG指数与正常健康个体血压升高风险呈正相关。本研究表明TyG指数可能作为高血压的潜在预测指标。然而，需要在纵向设计中对更大样本量和不同目标人群进行进一步研究。
