Afifi A K, Bergman R A, Zaynoun S T, Bahuth N B, Kraydieh M
J Am Acad Dermatol. 1985 Jan;12(1 Pt 2):198-203.
The light and electron microscopic myopathologic and dermatopathologic features in one patient with the partial (localized) type of lipodystrophy are described. The myopathologic changes involve both the contractile elements and the intracellular organelles, especially mitochondria that show hyperplasia and structural alterations of cristae. The dermatopathologic changes consist of a reduction in subcutaneous fat, intercellular edema, and the presence of intracytoplasmic lipid droplets. This is the first report in the literature in which the myopathologic features and detailed electron microscopy of skin in this condition are described. The myopathologic features of partial lipodystrophy are compared with those of congenital generalized lipodystrophy. It is proposed that a myopathy may be one of the manifestations of partial lipodystrophy.
本文描述了一名部分（局限性）型脂肪营养不良患者的光镜和电镜下的肌病及皮肤病理学特征。肌病性改变累及收缩成分和细胞内细胞器，尤其是线粒体，线粒体显示增生及嵴的结构改变。皮肤病理学改变包括皮下脂肪减少、细胞间水肿和胞质内脂滴的存在。这是文献中首次报道该病的肌病特征及皮肤的详细电镜表现。将部分脂肪营养不良的肌病特征与先天性全身性脂肪营养不良的特征进行了比较。有人提出肌病可能是部分脂肪营养不良的表现之一。
