Orrell R W, Peatfield R C, Collins C E, Woodrow D F, Moss J, Press M, Lane R J
Academic Unit of Neuroscience, Charing Cross and Westminster Medical School, London, UK.
Clin Neurol Neurosurg. 1995 May;97(2):181-6. doi: 10.1016/0303-8467(95)00021-b.
We describe two women with acquired partial lipodystrophy, one with significant myopathic symptoms and signs. Muscle biopsy of deltoid and quadriceps was performed in each case. The light microscopy findings were of type 1 and type 2 fibre hypertrophy, with an increase in intracytoplasmic fat in both cases. Electron microscopy showed normal fibres, with accumulations of electron-lucent fat droplets between the myofibrils. The cause of the lipodystrophies is uncertain, but myopathy may be a feature, and muscle biopsy studies may help in further defining the syndrome.
我们描述了两名患有获得性部分脂肪营养不良的女性，其中一名有明显的肌病症状和体征。对每位患者的三角肌和股四头肌进行了肌肉活检。光镜检查结果显示1型和2型肌纤维肥大，两例患者的胞浆内脂肪均增加。电镜检查显示纤维正常，肌原纤维之间有电子透亮脂肪滴积聚。脂肪营养不良的病因尚不确定，但肌病可能是其特征之一，肌肉活检研究可能有助于进一步明确该综合征。
