[Indirect comparison of anti-angiogenic agents in the treatment of diabetic macular edema].

UNLABELLED

Diabetic macular edema (DME) is a leading cause of visual impairment and blindness among diabetic patients, its prevalence is continuing to increase worldwide. Faricimab, a bispecific antibody, represents a new generation of treatments for DME.

PURPOSE

This study presents an indirect comparison of the effectiveness and safety of faricimab versus other treatment options for DME.

MATERIAL AND METHODS

This systematic review of the effectiveness and safety of intravitreal injections (IVIs) of anti-angiogenic agents was conducted using the PRISMA methodology. Randomized clinical trials (RCTs) with outcomes at 12 months of DME treatment were included for network meta-analysis (NMA). Six endpoints were evaluated: the change in best-corrected visual acuity (BCVA), central retinal thickness (CRT); number of IVIs; proportion of patients with improved/deteriorated vision (per ETDRS); incidence of ophthalmic adverse events; and probability of treatment discontinuation. Evidence network diagrams and forest plots for faricimab 6.0 mg in a personalized treatment interval (PTI) regimen (up to one injection every 16 weeks) compared to aflibercept 2 mg and ranibizumab 0.5 mg were generated using RStudio.

RESULTS

Of 2845 initial publications, 38 studies were reviewed, and 20 RCTs were included in the base NMA. A random-effects model was applied for the NMA of injection frequency due to high heterogeneity, while fixed-effect models were used for other endpoints. Faricimab 6 mg in the PTI regimen demonstrated superior or comparable functional (BCVA improvement) and anatomical (CRT reduction) outcomes over 12 months with fewer injections than aflibercept 2 mg or ranibizumab 0.5 mg. Safety outcomes were similar across all anti-angiogenic agents.

CONCLUSIONS

The clinical efficacy and safety of faricimab, aflibercept and ranibizumab are comparable in adult patients with DME with a fewer number of faricimab IVIs vs comparators.